| + |
muramyl dipeptide | up-regulates activity 
binding
|
NOD2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280446 |
|
|
Homo sapiens |
HT-29 Cell |
| pmid |
sentence |
| 23275943 |
MDP can activate several immune signaling pathways, including the NOD2-dependent pathway, through a specific interaction between NOD2 and MDP, resulting in nuclear factor-κB (NF-κB) activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC15A1 | up-regulates activity
binding
|
muramyl dipeptide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280445 |
|
|
Homo sapiens |
Caco-2/BBe Cell |
| pmid |
sentence |
| 15521010 |
HPepT1 transports muralyl dipeptide (MDP), activating NF-kB. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC15A4 | up-regulates activity 
relocalization
|
muramyl dipeptide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280448 |
|
|
Homo sapiens |
HEK-293-TrkB Cell |
| pmid |
sentence |
| 28450278 |
SLC15A4 regulate MDP transport via bacterial ligands internalized endosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
muramyl dipeptide | up-regulates activity
binding
|
TLR2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280447 |
|
|
Homo sapiens |
Colonic Epithelial Cell |
| pmid |
sentence |
| 38510686 |
The bacterial cell wall MDP (PGN) is a well-established Toll-like receptor 2 (TLR2) ligand, as demonstrated by the fact that TLR2-deficient mice display defective proinflammatory cytokine responses against PGN. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
muramyl dipeptide