Summary

Name SLC15A1
Full Name Solute carrier family 15 member 1
Synonyms Intestinal H(+, Oligopeptide transporter, small intestine isoform, Peptide transporter 1 | PEPT1
Primary ID P46059
Links - -
Type protein
Relations 1
Function Electrogenic proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and monovalently charged peptides with a proton to peptide stoichiometry of 1:1 or 2:1 (By similarity) (PubMed:15521010, PubMed:18367661, PubMed:19685173, PubMed:26320580, PubMed:7896779, PubMed:8914574, PubMed:9835627). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity). Mediates transepithelial transport of muramyl and N-formylated bacterial dipeptides contributing to recognition of pathogenic bacteria by the mucosal immune system (PubMed:15521010, PubMed:9835627). {ECO:0000250|UniProtKB:P36836, ECO:0000269|PubMed:15521010, ECO:0000269|PubMed:18367661, ECO:0000269|PubMed:19685173, ECO:0000269|PubMed:7896779, ECO:0000269|PubMed:8914574, ECO:0000269|PubMed:9835627}.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding muramyl dipeptide 0.8
Publications: 1 Organism: Homo Sapiens