| + |
Jervine | down-regulates
chemical inhibition
|
SMO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139865 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 16112412 |
Here, we demonstrate that cyclopamine and jervine, two structurally related inhibitors of smo, force ciliary translocation of smo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174420 |
|
|
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 21679342 |
Cyclopamine (c27h41no2) and jervine (c27h39no3) were discovered and in particular, a series of studies with the hh pathway inhibitor, cyclopamine, has brought about this expectation. cyclopamine suppresses the hh signaling pathway through direct interaction with smo. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |