Relation Results

Summary

Name paliperidone
Synonyms (+-)-paliperidone (ChemIDplus), (RS)-paliperidone (ChemIDplus), 9-hydroxy-risperidone (ChemIDplus), 9-Hydroxyrisperidone (DrugBank), 9-OH-risperidone (ChemIDplus), Invega (KEGG DRUG), paliperidone (KEGG DRUG), R 76477 (ChemIDplus), R-76477 (ChemIDplus), rac-paliperidone (ChemIDplus), racemic paliperidone (ChemIDplus), Ro-76477 (DrugBank), RO76477 (ChemIDplus)
IUPAC rac-3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Formula C23H27FN4O3
PRIMARY ID
(Read more)		 CHEBI:82978
Type chemical
Relations 6

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Type: Score: Layout: SPV 
0.80.80.80.80.80.8paliperidoneHTR1DHTR1BHTR1EHTR2AHTR1AHRH1

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Regulator
Mechanism
target
score ℹ
+ paliperidonedown-regulates activity img/direct_inhibition.png chemical inhibition HTR1D 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-258562 Rattus norvegicus C6 Glioma Cell
pmid sentence
Risperidone and its active metabolite 9-OH-risperidone were compared to reference antipsychotic drugs (haloperidol, pipamperone, fluspirilene, clozapine, zotepine) and compounds under development (olanzapine, seroquel, sertindole, ORG-5222, ziprasidone) for in vitro binding to neurotransmitter receptors in brain tissue and on membranes of recombinant cells expressing cloned human receptors and for in vivo occupancy of neurotransmitter receptors in rat and guinea-pig brain following acute treatment (2 h., s.c.). The binding affinities of the compounds for various neurotransmitter receptors were measured using membrane preparations of animal brain regions and of recombinant cells expressing cloned, mostly human receptors. Receptors, tissues and cells are indicated in Table I; results are shown in Table 4A-B.
Publications: 1 Organism: Rattus Norvegicus
+ paliperidonedown-regulates activity img/direct_inhibition.png chemical inhibition HTR1B 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-258560 Rattus norvegicus
pmid sentence
Risperidone and its active metabolite 9-OH-risperidone were compared to reference antipsychotic drugs (haloperidol, pipamperone, fluspirilene, clozapine, zotepine) and compounds under development (olanzapine, seroquel, sertindole, ORG-5222, ziprasidone) for in vitro binding to neurotransmitter receptors in brain tissue and on membranes of recombinant cells expressing cloned human receptors and for in vivo occupancy of neurotransmitter receptors in rat and guinea-pig brain following acute treatment (2 h., s.c.). The binding affinities of the compounds for various neurotransmitter receptors were measured using membrane preparations of animal brain regions and of recombinant cells expressing cloned, mostly human receptors. Receptors, tissues and cells are indicated in Table I; results are shown in Table 4A-B.
Publications: 1 Organism: Rattus Norvegicus
Tissue: Corpus Striatum
+ paliperidonedown-regulates activity img/direct_inhibition.png chemical inhibition HTR1E 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-258561 Chlorocebus aethiops COS-7 Cell
pmid sentence
Risperidone and its active metabolite 9-OH-risperidone were compared to reference antipsychotic drugs (haloperidol, pipamperone, fluspirilene, clozapine, zotepine) and compounds under development (olanzapine, seroquel, sertindole, ORG-5222, ziprasidone) for in vitro binding to neurotransmitter receptors in brain tissue and on membranes of recombinant cells expressing cloned human receptors and for in vivo occupancy of neurotransmitter receptors in rat and guinea-pig brain following acute treatment (2 h., s.c.). The binding affinities of the compounds for various neurotransmitter receptors were measured using membrane preparations of animal brain regions and of recombinant cells expressing cloned, mostly human receptors. Receptors, tissues and cells are indicated in Table I; results are shown in Table 4A-B.
Publications: 1 Organism: Chlorocebus Aethiops
+ paliperidonedown-regulates activity img/direct_inhibition.png chemical inhibition HTR2A 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-258564 Mus musculus
pmid sentence
Risperidone and its active metabolite 9-OH-risperidone were compared to reference antipsychotic drugs (haloperidol, pipamperone, fluspirilene, clozapine, zotepine) and compounds under development (olanzapine, seroquel, sertindole, ORG-5222, ziprasidone) for in vitro binding to neurotransmitter receptors in brain tissue and on membranes of recombinant cells expressing cloned human receptors and for in vivo occupancy of neurotransmitter receptors in rat and guinea-pig brain following acute treatment (2 h., s.c.). The binding affinities of the compounds for various neurotransmitter receptors were measured using membrane preparations of animal brain regions and of recombinant cells expressing cloned, mostly human receptors. Receptors, tissues and cells are indicated in Table I; results are shown in Table 4A-B.
Publications: 1 Organism: Mus Musculus
Tissue: L-929 Cell
+ paliperidonedown-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-258565 Rattus norvegicus
pmid sentence
Risperidone and its active metabolite 9-OH-risperidone were compared to reference antipsychotic drugs (haloperidol, pipamperone, fluspirilene, clozapine, zotepine) and compounds under development (olanzapine, seroquel, sertindole, ORG-5222, ziprasidone) for in vitro binding to neurotransmitter receptors in brain tissue and on membranes of recombinant cells expressing cloned human receptors and for in vivo occupancy of neurotransmitter receptors in rat and guinea-pig brain following acute treatment (2 h., s.c.). The binding affinities of the compounds for various neurotransmitter receptors were measured using membrane preparations of animal brain regions and of recombinant cells expressing cloned, mostly human receptors. Receptors, tissues and cells are indicated in Table I; results are shown in Table 4A-B.
Publications: 1 Organism: Rattus Norvegicus
Tissue: Hippocampus
+ paliperidonedown-regulates activity img/direct_inhibition.png chemical inhibition HRH1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-258563 in vitro
pmid sentence
Risperidone and its active metabolite 9-OH-risperidone were compared to reference antipsychotic drugs (haloperidol, pipamperone, fluspirilene, clozapine, zotepine) and compounds under development (olanzapine, seroquel, sertindole, ORG-5222, ziprasidone) for in vitro binding to neurotransmitter receptors in brain tissue and on membranes of recombinant cells expressing cloned human receptors and for in vivo occupancy of neurotransmitter receptors in rat and guinea-pig brain following acute treatment (2 h., s.c.). The binding affinities of the compounds for various neurotransmitter receptors were measured using membrane preparations of animal brain regions and of recombinant cells expressing cloned, mostly human receptors. Receptors, tissues and cells are indicated in Table I; results are shown in Table 4A-B.
Publications: 1 Organism: In Vitro
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