Summary

Name HTR1B
Full Name 5-hydroxytryptamine receptor 1B
Synonyms 5-HT-1B, 5-HT1B, S12, Serotonin 1D beta receptor, 5-HT-1D-beta, Serotonin receptor 1B | HTR1DB
Primary ID P28222
Links - -
Type protein
Relations 18
Inhibitors zotepine; risperidone; pipamperone; paliperidone; sertindole
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png chemical activation HTR1B 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAO1 0.464
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation HTR1B 0.8
Publications: 1 Organism: Rattus Norvegicus
Tissue: Corpus Striatum
+ up-regulates activity img/direct-activation.png binding GNA14 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.438
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1B 0.8
Publications: 1 Organism: Rattus Norvegicus
Tissue: Corpus Striatum
+ up-regulates activity img/direct-activation.png chemical activation HTR1B 0.8
Publications: 1 Organism: Rattus Norvegicus
Tissue: Corpus Striatum
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1B 0.8
Publications: 1 Organism: Rattus Norvegicus
Tissue: Corpus Striatum
+ up-regulates activity img/direct-activation.png chemical activation HTR1B 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1B 0.8
Publications: 1 Organism: Rattus Norvegicus
Tissue: Corpus Striatum
+ up-regulates activity img/direct-activation.png binding GNAI3 0.405
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation HTR1B 0.8
Publications: 1 Organism: Bos Taurus
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1B 0.8
Publications: 1 Organism: Rattus Norvegicus
Tissue: Corpus Striatum
+ up-regulates activity img/direct-activation.png chemical activation HTR1B 0.8
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png chemical activation HTR1B 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1B 0.8
Publications: 1 Organism: Rattus Norvegicus
Tissue: Corpus Striatum
+ up-regulates activity img/direct-activation.png chemical activation HTR1B 0.8
Publications: 1 Organism: Rattus Norvegicus
Tissue: Corpus Striatum
+ up-regulates activity img/direct-activation.png binding GNAZ 0.251
Publications: 1 Organism: Homo Sapiens