+ |
2-(4-morpholinyl)-6-(1-thianthrenyl)-4-pyranone | down-regulates activity
chemical inhibition
|
ATM |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262536 |
|
|
Homo sapiens |
SH-SY5Y Cell |
pmid |
sentence |
28341201 |
KU-55933 blocked phosphorylation of ATM in H2O2 and Dox models of cell damage. the neuroprotective efficacy of KU-55933, a potent inhibitor of ATM, against cell damage evoked by oxidative stress (hydrogen peroxide, H2O2) has been studied in human neuroblastoma SH-SY5Y cells and compared with the efficacy of this agent in models of doxorubicin (Dox)- and staurosporine (St)-evoked cell death. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
2-(4-morpholinyl)-6-(1-thianthrenyl)-4-pyranone | down-regulates
chemical inhibition
|
ATM |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-132441 |
|
|
Homo sapiens |
|
pmid |
sentence |
15604286 |
Through screening a small molecule compound library developed for the phosphatidylinositol 3'-kinase-like kinase family, we identified an atp-competitive inhibitor, 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one (ku-55933), that inhibits atm with an ic(50) of 13 nmol/l and a ki of 2.2 nmol/l |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-193600 |
|
|
Homo sapiens |
|
pmid |
sentence |
Other |
|
|
Publications: |
2 |
Organism: |
Homo Sapiens |