| + |
beta-alanine | up-regulates activity 
chemical activation
|
GLRA1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258581 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9009272 |
For each mutant GlyR we examined the agonist efficacies of taurine and β-alanine relative to glycine, the concentration of each agonist required for half-maximal current activation (EC50) and, in mutant GlyRs where β-alanine and taurine exhibited partial or no agonist efficacy, the concentration required for half-maximal inhibition of glycine-gated currents (IC50).experiments described in this report were performed on human α1 homomeric GlyRs recombinantly expressed in mammalian HEK 293 cells. Taurine and β-alanine act as full agonists of human α1 GlyRs when expressed in this system. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
beta-alanine | up-regulates activity
chemical activation
|
GlyR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270261 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9009272 |
For each mutant GlyR we examined the agonist efficacies of taurine and β-alanine relative to glycine, the concentration of each agonist required for half-maximal current activation (EC50) and, in mutant GlyRs where β-alanine and taurine exhibited partial or no agonist efficacy, the concentration required for half-maximal inhibition of glycine-gated currents (IC50).experiments described in this report were performed on human α1 homomeric GlyRs recombinantly expressed in mammalian HEK 293 cells. Taurine and β-alanine act as full agonists of human α1 GlyRs when expressed in this system. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267795 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9009272 |
For each mutant GlyR we examined the agonist efficacies of taurine and beta-alanine relative to glycine, the concentration of each agonist required for half-maximal current activation (EC50) and, in mutant GlyRs where beta-alanine and taurine exhibited partial or no agonist efficacy, the concentration required for half-maximal inhibition of glycine-gated currents (IC50).experiments described in this report were performed on human alpha-1 homomeric GlyRs recombinantly expressed in mammalian HEK 293 cells. Taurine and beta-alanine act as full agonists of huma nalpha-1 GlyRs when expressed in this system. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
beta-alanine