| + |
taurine | up-regulates activity 
chemical activation
|
GlyR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267793 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9009272 |
For each mutant GlyR we examined the agonist efficacies of taurine and beta-alanine relative to glycine, the concentration of each agonist required for half-maximal current activation (EC50) and, in mutant GlyRs where beta-alanine and taurine exhibited partial or no agonist efficacy, the concentration required for half-maximal inhibition of glycine-gated currents (IC50).experiments described in this report were performed on human alpha-1 homomeric GlyRs recombinantly expressed in mammalian HEK 293 cells. Taurine and beta-alanine act as full agonists of huma nalpha-1 GlyRs when expressed in this system. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270259 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9009272 |
For each mutant GlyR we examined the agonist efficacies of taurine and β-alanine relative to glycine, the concentration of each agonist required for half-maximal current activation (EC50) and, in mutant GlyRs where β-alanine and taurine exhibited partial or no agonist efficacy, the concentration required for half-maximal inhibition of glycine-gated currents (IC50).experiments described in this report were performed on human α1 homomeric GlyRs recombinantly expressed in mammalian HEK 293 cells. Taurine and β-alanine act as full agonists of human α1 GlyRs when expressed in this system. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SRC | up-regulates
phosphorylation
|
GlyR |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270262 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 11882681 |
These findings indicate that glyr function is upregulated by ptks and this modulation is dependent on the tyrosine-413 residue of the beta subunit. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain, Kidney |
| + |
SRC | up-regulates activity
phosphorylation
|
GlyR |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267796 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 11882681 |
These findings indicate that glyr function is upregulated by ptks and this modulation is dependent on the tyrosine-413 residue of the beta subunit. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain, Kidney |
| + |
GlyR | up-regulates quantity
relocalization
|
chloride |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264984 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18721822 |
The glycine receptor chloride channel (GlyR), a member of the pentameric Cys-loop ion channel receptor family, mediates inhibitory neurotransmission in the spinal cord, brainstem and retina. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | GABAergic synapse |
| + |
glycine | up-regulates activity
chemical activation
|
GlyR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264985 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18721822 |
The glycine receptor chloride channel (GlyR), a member of the pentameric Cys-loop ion channel receptor family, mediates inhibitory neurotransmission in the spinal cord, brainstem and retina. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | GABAergic synapse |
| + |
beta-alanine | up-regulates activity
chemical activation
|
GlyR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267795 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9009272 |
For each mutant GlyR we examined the agonist efficacies of taurine and beta-alanine relative to glycine, the concentration of each agonist required for half-maximal current activation (EC50) and, in mutant GlyRs where beta-alanine and taurine exhibited partial or no agonist efficacy, the concentration required for half-maximal inhibition of glycine-gated currents (IC50).experiments described in this report were performed on human alpha-1 homomeric GlyRs recombinantly expressed in mammalian HEK 293 cells. Taurine and beta-alanine act as full agonists of huma nalpha-1 GlyRs when expressed in this system. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270261 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9009272 |
For each mutant GlyR we examined the agonist efficacies of taurine and β-alanine relative to glycine, the concentration of each agonist required for half-maximal current activation (EC50) and, in mutant GlyRs where β-alanine and taurine exhibited partial or no agonist efficacy, the concentration required for half-maximal inhibition of glycine-gated currents (IC50).experiments described in this report were performed on human α1 homomeric GlyRs recombinantly expressed in mammalian HEK 293 cells. Taurine and β-alanine act as full agonists of human α1 GlyRs when expressed in this system. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ethanol | up-regulates activity
chemical activation
|
GlyR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270260 |
|
|
Xenopus laevis |
Oocyte |
| pmid |
sentence |
| 8700149 |
Pharmacologically relevant concentrations of ethanol (10-200 mM) reversibly potentiated the glycine receptor function in all receptors. Ethanol potentiation depended on the glycine concentration used, with decreased potentiation observed at higher glycine concentrations. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267794 |
|
|
Xenopus laevis |
Oocyte |
| pmid |
sentence |
| 8700149 |
Pharmacologically relevant concentrations of ethanol (10-200 mM) reversibly potentiated the glycine receptor function in all receptors. Ethanol potentiation depended on the glycine concentration used, with decreased potentiation observed at higher glycine concentrations. |
|
| Publications: |
2 |
Organism: |
Xenopus Laevis |
3.0
GlyR