| + |
leucine | down-regulates activity 
chemical inhibition
|
SESN2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254897 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26449471 |
We find that leucine, but not arginine, disrupts the Sestrin2- GATOR2 interaction by binding to Sestrin2 with a dissociation constant of 20micromolar, which is the leucine concentration that half-maximally activates mTORC1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
leucine | up-regulates activity 
|
mTORC1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268010 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22749528 |
Leucine and Glutamine Activate Glutaminolysis and mTORC1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC38A9 | up-regulates quantity 
relocalization
|
leucine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255313 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29053970 |
SLC38A9 mediates the transport, in an arginine-regulated fashion, of many essential amino acids out of lysosomes, including leucine, which mTORC1 senses through the cytosolic Sestrin proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
leucine | up-regulates quantity
|
AminoAcids |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264748 |
|
|
|
|
| pmid |
sentence |
| 29259120 |
All extant life employs the same 20 amino acids for protein biosynthesis |
|
| Publications: |
1 |
| + |
Multiaminoacyl-tRNA synthetase | down-regulates quantity
chemical modification
|
leucine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270413 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28271488 |
Aminoacyl-tRNA synthetases (AARSs) are essential enzymes that specifically aminoacylate one tRNA molecule by the cognate amino acid. In mammals, nine synthetases, those specific for amino acids Arg, Asp, Gln, Glu, Ile, Leu, Lys, Met and Pro, associate into a multi-aminoacyl-tRNA synthetase complex, an association which is believed to play a key role in the cellular organization of translation, but also in the regulation of the translational and nontranslational functions of these enzymes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
leucine | up-regulates quantity
precursor of
|
Leu-tRNA(Leu) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270418 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28271488 |
Aminoacyl-tRNA synthetases (AARSs) are essential enzymes that specifically aminoacylate one tRNA molecule by the cognate amino acid. In mammals, nine synthetases, those specific for amino acids Arg, Asp, Gln, Glu, Ile, Leu, Lys, Met and Pro, associate into a multi-aminoacyl-tRNA synthetase complex, an association which is believed to play a key role in the cellular organization of translation, but also in the regulation of the translational and nontranslational functions of these enzymes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
leucine | up-regulates activity
|
Glutaminolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268011 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22749528 |
Leucine and Glutamine Activate Glutaminolysis and mTORC1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
leucine