| + |
Alkannin | down-regulates activity 
chemical inhibition
|
PK |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270284 |
|
|
Homo sapiens |
MCF-7 Cell, A-549 Cell |
| pmid |
sentence |
| 21516121 |
Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. |Shikonin and alkannin are potent inhibitors of recombinant human PKM2|Shikonin and alkannin significantly inhibited the glycolytic rate, as manifested by cellular lactate production and glucose consumption in drug-sensitive and resistant cancer cell lines (MCF-7, MCF-7/Adr, MCF-7/Bcl-2, MCF-7/Bcl-x(L) and A549) that primarily express PKM2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Alkannin | down-regulates activity
chemical inhibition
|
PKM |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262009 |
|
|
Homo sapiens |
MCF-7 Cell, A-549 Cell |
| pmid |
sentence |
| 21516121 |
Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. |Shikonin and alkannin are potent inhibitors of recombinant human PKM2|Shikonin and alkannin significantly inhibited the glycolytic rate, as manifested by cellular lactate production and glucose consumption in drug-sensitive and resistant cancer cell lines (MCF-7, MCF-7/Adr, MCF-7/Bcl-2, MCF-7/Bcl-x(L) and A549) that primarily express PKM2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Alkannin
