| + |
CTH | down-regulates quantity 
chemical modification
|
L-homocysteine zwitterion |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275825 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19961860 |
the role of CSE in this reaction pathway is to convert l-cystathionine into l-cysteine whilst generating α-ketobutyrate and ammonia (Fig. 1). The reaction proceeds via an α,γ-elimination mechanism where the C–γ–S bond of l-cystathionine is specifically cleaved to yield l-cysteine.12 Defects in this metabolic pathway are associated with cystathioninuria, l-cysteine deficiency and subsequent impairment of glutathione metabolism, as well as higher plasma homocysteine concentrations.13, 14, 15, 16, 17 Besides its role in the conversion of l-cystathionine into l-cysteine, studies have also shown that CSE can utilize l-cysteine as a substrate for producing H2S via an α,β-elimination reaction (Fig. 1).18, 19, 20 However, to date, no reports have clearly demonstrated the residues that affect CSE-mediated H2S production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney, Liver, Vascular Cell |
| + |
L-homocysteine zwitterion | up-regulates quantity 
precursor of
|
L-cystathionine dizwitterion |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275826 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23981774 |
Cystathionine β-synthase (CBS) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the condensation of homocysteine with serine to generate cystathionine. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
L-homocysteine zwitterion | up-regulates quantity
precursor of
|
hydrosulfide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275816 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19961860 |
the role of CSE in this reaction pathway is to convert l-cystathionine into l-cysteine whilst generating α-ketobutyrate and ammonia (Fig. 1). The reaction proceeds via an α,γ-elimination mechanism where the C–γ–S bond of l-cystathionine is specifically cleaved to yield l-cysteine.12 Defects in this metabolic pathway are associated with cystathioninuria, l-cysteine deficiency and subsequent impairment of glutathione metabolism, as well as higher plasma homocysteine concentrations.13, 14, 15, 16, 17 Besides its role in the conversion of l-cystathionine into l-cysteine, studies have also shown that CSE can utilize l-cysteine as a substrate for producing H2S via an α,β-elimination reaction (Fig. 1).18, 19, 20 However, to date, no reports have clearly demonstrated the residues that affect CSE-mediated H2S production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney, Liver, Vascular Cell |
| + |
CBS | down-regulates quantity
chemical modification
|
L-homocysteine zwitterion |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275828 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23981774 |
Cystathionine β-synthase (CBS) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the condensation of homocysteine with serine to generate cystathionine. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
L-homocysteine zwitterion