| + |
CBS | down-regulates quantity 
chemical modification
|
L-serine zwitterion |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275829 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23981774 |
Cystathionine β-synthase (CBS) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the condensation of homocysteine with serine to generate cystathionine. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CBS | down-regulates quantity
chemical modification
|
L-homocysteine zwitterion |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275828 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23981774 |
Cystathionine β-synthase (CBS) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the condensation of homocysteine with serine to generate cystathionine. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF1 | up-regulates quantity by expression 
transcriptional regulation
|
CBS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254814 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12427542 |
We previously described essential transactivating roles for specificity protein 1 (Sp1), Sp3, nuclear factor Y (NF-Y), and USF-1 in the regulation of the CBS-1b promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP3 | up-regulates quantity by expression
transcriptional regulation
|
CBS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254813 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12427542 |
We previously described essential transactivating roles for specificity protein 1 (Sp1), Sp3, nuclear factor Y (NF-Y), and USF-1 in the regulation of the CBS-1b promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CBS | up-regulates quantity 
chemical modification
|
L-cystathionine dizwitterion |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275830 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23981774 |
Cystathionine β-synthase (CBS) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the condensation of homocysteine with serine to generate cystathionine. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFYA | up-regulates quantity by expression
transcriptional regulation
|
CBS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254815 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12427542 |
Our results further confirm the important transactivating role for NF-Y for the CBS-1b promoter, via its synergism with Sp1. While differential phosphorylation of Sp1 likely contributes to binding to multiple GC-/GT-boxes in the CBS-1b and promoter activation [16], NF-Y is clearly necessary for a maximal activation response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
CBS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254812 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12427542 |
We previously described essential transactivating roles for specificity protein 1 (Sp1), Sp3, nuclear factor Y (NF-Y), and USF-1 in the regulation of the CBS-1b promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CBS
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