| + |
PRKCA |
phosphorylation
|
SNAP23 |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249227 |
Ser161 |
ENLTQVGsILGNLKD |
Homo sapiens |
|
| pmid |
sentence |
| 12930825 |
Ion trap mass spectrometry revealed that platelet SNAP-23 was phosphorylated at Ser23/Thr24 and Ser161, after cell activation by thrombin; these sites were also identified in PKC-phosphorylated r-SNAP-23. SNAP-23 mutants that mimic phosphorylation at Ser23/Thr24 inhibited syntaxin 4 interactions, whereas a phosphorylation mutant of Ser161 had only minor effects. | Because mutants that mimic SNAP-23 phosphorylation affect syntaxin 4 interactions, we hypothesize that SNAP-23 phosphorylation may be important for modulating SNARE-complex interactions during membrane trafficking and fusion. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249228 |
Ser23 |
ITDESLEsTRRILGL |
Homo sapiens |
|
| pmid |
sentence |
| 12930825 |
Ion trap mass spectrometry revealed that platelet SNAP-23 was phosphorylated at Ser23/Thr24 and Ser161, after cell activation by thrombin; these sites were also identified in PKC-phosphorylated r-SNAP-23. SNAP-23 mutants that mimic phosphorylation at Ser23/Thr24 inhibited syntaxin 4 interactions, whereas a phosphorylation mutant of Ser161 had only minor effects. | Because mutants that mimic SNAP-23 phosphorylation affect syntaxin 4 interactions, we hypothesize that SNAP-23 phosphorylation may be important for modulating SNARE-complex interactions during membrane trafficking and fusion. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249229 |
Thr24 |
TDESLEStRRILGLA |
Homo sapiens |
|
| pmid |
sentence |
| 12930825 |
Ion trap mass spectrometry revealed that platelet SNAP-23 was phosphorylated at Ser23/Thr24 and Ser161, after cell activation by thrombin; these sites were also identified in PKC-phosphorylated r-SNAP-23. SNAP-23 mutants that mimic phosphorylation at Ser23/Thr24 inhibited syntaxin 4 interactions, whereas a phosphorylation mutant of Ser161 had only minor effects. | Because mutants that mimic SNAP-23 phosphorylation affect syntaxin 4 interactions, we hypothesize that SNAP-23 phosphorylation may be important for modulating SNARE-complex interactions during membrane trafficking and fusion. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
SNAP23 | form complex 
binding
|
STX11-SNAP23 SNARE complex |
0.735 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261895 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 22767500 |
Coimmunoprecipitation experiments showed that syntaxin-11 can form SNARE complexes with both VAMP-8 and SNAP-23. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SNAP23
- 
- 