4.0
Summary
| Name |  HAX1View Modifications |
| Full Name | HCLS1-associated protein X-1 |
| Synonyms | HS1-associating protein X-1, HAX-1, HS1-binding protein 1, HSP1BP-1 | HS1BP1 |
| Primary ID | O00165 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484). Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCD | down-regulates quantity by destabilization 
phosphorylation
|
HAX1 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | HAX1 | down-regulates quantity by destabilization
binding
|
ATP2A2 | 0.367 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FBXO25 | down-regulates quantity by destabilization
ubiquitination
|
HAX1 | 0.328 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | HAX1 | down-regulates quantity by repression 
transcriptional regulation
|
ATP2A2 | 0.367 |
| Publications: | 1 | Organism: | Homo Sapiens | |