| + |
PRKCD | up-regulates activity 
phosphorylation
|
FBXO25 |
0.277 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275561 |
Ser178 |
DLLQDLSsTLCILIR |
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 25419709 |
FBXO25 encodes an orphan F-box protein that determines the substrate specificity of the SCF (SKP1-CUL1-F-box)(FBXO25) ubiquitin ligase complex. An unbiased screen uncovered the prosurvival protein HCLS1-associated protein X-1 (HAX-1) as the bona fide substrate of FBXO25 that is targeted after apoptotic stresses. Protein kinase Cdelta (PRKCD) initiates this process by phosphorylating FBXO25 and HAX-1, thereby spatially directing nuclear FBXO25 to mitochondrial HAX-1.|Accordingly, PRKCD-induced phosphorylation of Hax-1 at Ser210 and Fbxo25 at Ser178 was associated with decreased expression of Hax-1 in control cells, |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FBXO25 | down-regulates quantity by destabilization 
binding
|
ELK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272127 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23940030 |
The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. FBXO25 is one of the 69 known human F-box proteins that serve as specificity factors for a family of ubiquitin ligases composed of SKP1, Rbx1, Cullin1, and F-box protein (SCF1) that are involved in targeting proteins for degradation across the ubiquitin proteasome system. FBXO25 interacted with and mediated the ubiquitination and proteasomal degradation of ELK-1 in HEK293T cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXO25 | up-regulates activity
binding
|
Cullin 1-RBX1-Skp1 |
0.589 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272128 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23940030 |
The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. FBXO25 is one of the 69 known human F-box proteins that serve as specificity factors for a family of ubiquitin ligases composed of SKP1, Rbx1, Cullin1, and F-box protein (SCF1) that are involved in targeting proteins for degradation across the ubiquitin proteasome system. FBXO25 interacted with and mediated the ubiquitination and proteasomal degradation of ELK-1 in HEK293T cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXO25 | down-regulates quantity by destabilization
ubiquitination
|
HAX1 |
0.342 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275563 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 25419709 |
FBXO25 encodes an orphan F-box protein that determines the substrate specificity of the SCF (SKP1-CUL1-F-box)(FBXO25) ubiquitin ligase complex. An unbiased screen uncovered the prosurvival protein HCLS1-associated protein X-1 (HAX-1) as the bona fide substrate of FBXO25 that is targeted after apoptotic stresses. Protein kinase Cdelta (PRKCD) initiates this process by phosphorylating FBXO25 and HAX-1, thereby spatially directing nuclear FBXO25 to mitochondrial HAX-1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
FBXO25
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