| + |
GATA2 | up-regulates activity 
binding
|
ETV2 |
0.449 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256008 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24583263 |
Transcriptional assays with the Spi1 promoter-reporter demonstrated that Gata2 cooperates with Etv2 and augments the transcriptional activity of Etv2.The protein-protein interaction between Etv2 and Gata2 is mediated by the Ets and Gata domains. Using the embryoid body differentiation system, we demonstrate that co-expression of Gata2 augments the activity of Etv2 in promoting endothelial and hematopoietic lineage differentiation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ETV2 | up-regulates 
|
Differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256009 |
|
|
Mus musculus |
Embryonic Stem Cell |
| pmid |
sentence |
| 24583263 |
Using the embryoid body differentiation system, we demonstrate that co-expression of Gata2 augments the activity of Etv2 in promoting endothelial and hematopoietic lineage differentiation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ETV2 | up-regulates quantity by expression
transcriptional regulation
|
SPI1 |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256006 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24583263 |
We also identify Spi1 as a common downstream target gene of Etv2 and Gata2. We provide evidence that Etv2 and Gata2 bind to the Spi1 promoter in vitro and in vivo. Etv2 and Gata2 synergistically transactivate Spi1 gene expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ETV2 | up-regulates quantity by expression
transcriptional regulation
|
FLI1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203272 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24727028 |
We have identified a novel positive feed-forward regulatory loop in which etv2 activates expression of genes involved in vasculogenesis, including fli1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ETV2
- 
- 