| + |
HRAS | up-regulates activity 
phosphorylation
|
GATA2 |
0.368 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259945 |
Ser192 |
PSTTGAAsPASSSAG |
Homo sapiens |
|
| pmid |
sentence |
| 25056917 |
Oncogenic Ras enhanced S192-dependent GATA-2 phosphorylation, nuclear foci localization, and transcriptional activation. These studies define a mechanism that controls a key regulator of hematopoiesis and a dual mode of impairing GATA-2-dependent genetic networks: mutational disruption of chromatin occupancy yielding insufficient GATA-2, and oncogenic Ras-mediated amplification of GATA-2 activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
AKT | down-regulates activity 
phosphorylation
|
GATA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244271 |
Ser401 |
QTRNRKMsNKSKKSK |
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 15837948 |
We show that insulin induces gata2 phosphorylation on serine 401 in a pi-3k/akt-dependent manner. Insulin-dependent phosphorylation of serine 401 impairs gata2 translocation to the nucleus and its dna binding activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FAP: Insulin-mediated adipogenesis, Thyroid Hormone Metabolism |
| + |
AKT1 | down-regulates
phosphorylation
|
GATA2 |
0.545 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135614 |
Ser401 |
QTRNRKMsNKSKKSK |
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 15837948 |
We show that insulin induces gata2 phosphorylation on serine 401 in a pi-3k/akt-dependent manner. Insulin-dependent phosphorylation of serine 401 impairs gata2 translocation to the nucleus and its dna binding activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis |
| + |
FBXW7 | down-regulates quantity by destabilization
ubiquitination
|
GATA2 |
0.398 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256005 |
Thr176 |
HLFGFPPtPPKEVSP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25670854 |
Here, we demonstrate that F-box/WD repeat-containing protein 7 (Fbw7/Fbxw7), a component of Skp1, Cullin 1, F-box-containing complex (SCF)-type E3 ligase, is an E3 ligase for GATA2. GATA2 contains a cell division control protein 4 (Cdc4) phosphodegron (CPD), a consensus motif for ubiquitylation by Fbw7, which includes Thr(176). Ectopic expression of Fbw7 destabilized GATA2 and promoted its proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA2 | down-regulates quantity
transcriptional regulation
|
PPARG |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259949 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19772889 |
These findings indicate that fatty marrow replacement in AA patients can be explained by downregulation of GATA-2 and overexpression of PPARgamma in MSCs. Decreased expression of GATA-2 might be responsible for the pathogenesis and development of the clinical features of the disease. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, FAP: Insulin-mediated adipogenesis |
| + |
MECOM | up-regulates quantity by expression 
transcriptional regulation
|
GATA2 |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266062 |
|
|
Homo sapiens |
HEL Cell |
| pmid |
sentence |
| 15889140 |
Evi1 directly binds to the promoter region of GATA-2 and thus enhances the GATA-2 transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA2 | down-regulates 
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78659 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11021798 |
Constitutive gata-2 and gata-3 expression suppressed adipocyte differentiation and trapped cells at the preadipocyte stage. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis, FAP: Insulin-mediated adipogenesis, Thyroid Hormone Metabolism |
| + |
RAD21 | down-regulates activity
relocalization
|
GATA2 |
0.336 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261513 |
|
|
Homo sapiens |
Acute Myeloid Leukemia Cell |
| pmid |
sentence |
| 26607380 |
Large-scale AML genome re-sequencing efforts have identified novel recurrently mutated genes, including the members of the cohesin complex (RAD21, SMC3, SMC1A, and STAG2), implicated in the pathogenesis of this disease.Using ATAC-seq, we determined that mutant cohesin lead to a state of elevated chromatin accessibility and higher predicted binding at transcription factor binding sites for ERG, GATA2, and RUNX1. Moreover, using ChIP-Seq, we formally demonstrated increased binding of GATA2 and RUNX1 to these sites. Finally, we demonstrated that knockdown of these three TFs in human HSPC can revert the differentiation block induced by mutant cohesin. These results support a model in which mutant cohesin impairs hematopoietic differentiation and enforces stem cell programs through the modulation of ERG, GATA2, and RUNX1 chromatin accessibility, expression, and activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA1 | down-regulates quantity by repression
transcriptional regulation
|
GATA2 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256058 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12432220 |
Closer examination revealed a cross-regulatory mechanism by which GATA-1 can control the expression of GATA-2 and vice versa, possibly via essential GATA binding sites in their cis-acting elements.In this model, GATA-2 activates GATA-1 gene expression, while GATA-1 represses GATA-2 gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
GATA2 | up-regulates quantity by expression
transcriptional regulation
|
SPI1 |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256007 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24583263 |
We also identify Spi1 as a common downstream target gene of Etv2 and Gata2. We provide evidence that Etv2 and Gata2 bind to the Spi1 promoter in vitro and in vivo. Etv2 and Gata2 synergistically transactivate Spi1 gene expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
GATA2 | up-regulates quantity by expression
transcriptional regulation
|
TRH |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267259 |
|
|
Chlorocebus aethiops |
CV-1 Cell |
| pmid |
sentence |
| 33201916 |
The rat prepro-TRH gene is activated by GATA2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267258 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 33201916 |
The rat prepro-TRH gene is activated by GATA2. |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | Thyroid Hormone Metabolism |
| + |
MAPK14 | up-regulates
phosphorylation
|
GATA2 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205242 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25056917 |
P38_ increases gata_2 activity at endogenous target genes by inducing gata_2 multi_site phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
GATA2 | up-regulates quantity by expression
transcriptional regulation
|
GATA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256090 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27545880 |
GATA-2 phosphorylation facilitates GATA-2 chromatin occupancy at GATA-2 target genes. GATA-2 stimulates GATA2 transcription through positive autoregulation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, HaematopoiesisTranscriptionalControl, FAP: Insulin-mediated adipogenesis, Thyroid Hormone Metabolism |
| + |
GATA2 | up-regulates activity
|
Megakaryocyte_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259960 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21605981 |
GATA1 and GATA2 are expressed principally in hematopoietic lineages, and have essential roles in the development of multiple hematopoietic cells, including erythrocytes and megakaryocytes. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
THR | down-regulates activity
binding
|
GATA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267275 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29407449 |
We found that the T3-bound TR inhibits this reporter construct driven by GATA2 alone, indicating that the target of T3-bound TR repression is GATA2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Hypophysis |
| Pathways: | Thyroid Hormone Metabolism |
| + |
GATA2 | up-regulates quantity by expression
transcriptional regulation
|
KLF1 |
0.448 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256052 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 8195185 |
Regulation of the Erythroid Kruppel-like Factor (EKLF) Gene Promoter by the Erythroid Transcription Factor GATA-l.Accordingly,we have also demonstrated that GATA-2, like GATA-1, is able to activate the EKLF promoter in NIH3T3. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
GATA2 | down-regulates activity
|
PPARG |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132949 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20510530 |
GATA2 interacts directly with PPARG and C/EBP a , which may deplete PPARG involved in the promotion of adipogenesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, FAP: Insulin-mediated adipogenesis |
| + |
GATA2 | up-regulates quantity by expression
transcriptional regulation
|
GATA1 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256062 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21853041 |
GATA-2 induces the expression of GATA-1, which first activates its cofactor FOG-1, and then downregulates GATA-2 cooperatively with FOG-1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256056 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12432220 |
Closer examination revealed a cross-regulatory mechanism by which GATA-1 can control the expression of GATA-2 and vice versa, possibly via essential GATA binding sites in their cis-acting elements.In this model, GATA-2 activates GATA-1 gene expression, while GATA-1 represses GATA-2 gene expression. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
INS | down-regulates
|
GATA2 |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135617 |
|
|
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 15837948 |
We show that insulin induces gata2 phosphorylation on serine 401 in a pi-3k/akt-dependent manner. Insulin-dependent phosphorylation of serine 401 impairs gata2 translocation to the nucleus and its dna binding activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, FAP: Insulin-mediated adipogenesis |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
GATA2 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259946 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25056917 |
P38α promotes multi‐site GATA‐2 phosphorylation, increasing its localization in nuclear foci enriched in an active form of RNA polymerase II and its capacity to regulate endogenous target genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
PML-RARalpha | up-regulates activity
binding
|
GATA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259941 |
|
|
Mus musculus |
BA/F3 Cell |
| pmid |
sentence |
| 10938104 |
We provide evidence that GATA-2 can physically associate with PML-RARα. Functional experiments further demonstrated that this interaction has the capacity to render GATA-dependent transcription inducible by retinoic acid, raising the possibility that GATA target genes may be involved in the molecular pathogenesis of APL. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ZC3H12A | up-regulates quantity
post transcriptional regulation
|
GATA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259943 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 30842549 |
Here, we show that Regnase-1 regulates self-renewal of HSPCs through modulating the stability of Gata2 and Tal1 mRNA |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA2 | down-regulates quantity
transcriptional regulation
|
CYBB |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259948 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10734088 |
These results suggest that GATA-1 is an activator and that GATA-2 is a relative competitive inhibitor of GATA-1 in the expression of the gp91(phox) gene in human eosinophils. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NANOG | down-regulates quantity by repression
transcriptional regulation
|
GATA2 |
0.362 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254625 |
|
|
Homo sapiens |
Embryonic Stem Cell, Embryonic Carcinoma Cell |
| pmid |
sentence |
| 15983365 |
Transfection of NANOG-specific small interfering RNAs reduced levels of NANOG transcript and protein and induced activation of the extraembryonic endoderm-associated genes GATA4, GATA6, LAMININ B1, and AFP as well as upregulation of trophectoderm-associated genes CDX2, GATA2, hCG-alpha, and hCG-beta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
THRA | down-regulates activity
binding
|
GATA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267257 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29407449 |
We found that the T3-bound TR inhibits this reporter construct driven by GATA2 alone, indicating that the target of T3-bound TR repression is GATA2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Hypophysis |
| Pathways: | Thyroid Hormone Metabolism |
| + |
SPI1 | down-regulates quantity by repression
transcriptional regulation
|
GATA2 |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256069 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12433372 |
Using these progenitors and a conditionally activatable PU.1 protein, we show that PU.1 can negatively regulate expression of the GATA-2 gene.The above experiments suggested that PU.1 may physiologically downregulate the expression of the GATA-2 gene during the differentiation of myeloid progenitors into macrophages. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
GATA2 | up-regulates quantity by expression
transcriptional regulation
|
TSHB |
0.407 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267253 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9305891 |
Pit-1, is necessary but not sufficient to allow basal transcription of the mTSHβ gene.The analysis of the mTSHβ gene described in this report provides evidence for the participation of a zinc finger factor, GATA-2, with a POU homeodomain partner, Pit-1, on a such a composite element.In summary, we have shown the requirement for at least two different classes of transcription factors to regulate mTSHβ gene expression. Both GATA-2 and Pit-1 can bind independently to the P1 region of the promoter, form a heteromeric complex with DNA, and functionally synergize to activate TSHβ promoter activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Hypophysis |
| Pathways: | Thyroid Hormone Metabolism |
| + |
GATA2 | down-regulates activity
binding
|
SPI1 |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256071 |
|
|
Homo sapiens |
K-562 Cell |
| pmid |
sentence |
| 10411939 |
Here we demonstrate that a region of the PU.1 Ets domain (the winged helix–turn–helix wing) interacts with the conserved carboxyl-terminal zinc finger of GATA-1 and GATA-2 and that GATA proteins inhibit PU.1 transactivation of critical myeloid target genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
GATA2 | up-regulates activity
|
Mast-Cell_diff |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259959 |
|
|
Mus musculus |
Mast Cell |
| pmid |
sentence |
| 25801432 |
We have identified GATA2 as an essential transcription factor in differentiation of newly identified common basophil and mast cell progenitors into basophils and mast cells. ll differentiation and maintenance |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ZFPM1 | down-regulates quantity by repression
transcriptional regulation
|
GATA2 |
0.736 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256061 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21853041 |
GATA-2 induces the expression of GATA-1, which first activates its cofactor FOG-1, and then downregulates GATA-2 cooperatively with FOG-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
GATA1 | down-regulates quantity by repression
transcriptional regulation
|
GATA2 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256060 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21853041 |
GATA-2 induces the expression of GATA-1, which first activates its cofactor FOG-1, and then downregulates GATA-2 cooperatively with FOG-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
GATA2 | up-regulates activity
binding
|
ETV2 |
0.45 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256008 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24583263 |
Transcriptional assays with the Spi1 promoter-reporter demonstrated that Gata2 cooperates with Etv2 and augments the transcriptional activity of Etv2.The protein-protein interaction between Etv2 and Gata2 is mediated by the Ets and Gata domains. Using the embryoid body differentiation system, we demonstrate that co-expression of Gata2 augments the activity of Etv2 in promoting endothelial and hematopoietic lineage differentiation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
THRB | down-regulates activity
binding
|
GATA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267256 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29407449 |
We found that the T3-bound TR inhibits this reporter construct driven by GATA2 alone, indicating that the target of T3-bound TR repression is GATA2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Hypophysis |
| Pathways: | Thyroid Hormone Metabolism |
| + |
SMO | up-regulates activity
|
GATA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251656 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 16399502 |
In mammalian models [...] Hh signaling also inhibits mammalian adipogenesis. Hh signals elicit this function early in adipogenesis, upstream of PPARγ, potentially diverting preadipocytes as well as multipotent mesenchymal prescursors away from adipogenesis and toward osteogenesis. Hh may elicit these effects by inducing the expression of antiadipogenic transcription factors such as Gata2. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
GATA2
- 
- 