Summary

Name PDE2A
Full Name cGMP-dependent 3',5'-cyclic phosphodiesterase
Synonyms Cyclic GMP-stimulated phosphodiesterase, CGS-PDE, cGSPDE |
Primary ID O00408
Links - -
Type protein
Relations 3
Inhibitors caffeine
Function Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line) (PubMed:24705027).

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding PRKACA 0.375
Publications: 1
+ down-regulates activity img/direct_inhibition.png binding PKA 0.392
Publications: 1
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDE2A 0.8
Publications: 1