Summary

Name PRKACA
Full Name cAMP-dependent protein kinase catalytic subunit alpha
Synonyms PKA C-alpha | PKACA
Primary ID P17612
Links - -
Type protein
Relations 399
Pathways COVID-19 Causal Network, FAP: In vitro induction of adipogenesis, FAP: IBMX/rosiglitazone, FAP: GCR-cAMP crosstalk, Sonic Hedgehog, Myofiber: hypertrophy_cAMP, Pericyte: In vitro induction of adipogenesis, SARS-CoV ATTACHMENT AND ENTRY, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
Inhibitors N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide
Function Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation NF2 0.381
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SYN2 0.333
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation DNAJC5 0.332
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation GLI3 0.447
Publications: 6 Organism: Homo Sapiens
Pathways:Sonic Hedgehog
+ up-regulates activity img/direct-activation.png phosphorylation PHKA1 0.422
Publications: 2 Organism: , Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ITGA4 0.475
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ABCA1 0.49
Publications: 2 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation CIITA 0.315
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HAND1 0.301
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation H3-3A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.2
Publications: 3 Organism: Homo Sapiens
Tissue: Ovary
+ down-regulates img/direct_inhibition.png phosphorylation PLCB3 0.262
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CACNA1H 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KCNH2 0.313
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PRKAR2B 0.878
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TENT2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOS3 0.375
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATP2B1 0.442
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.526
Publications: 6 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.526
Publications: 3 Organism: Chlorocebus Aethiops, Homo Sapiens, In Vitro
Pathways:COVID-19 Causal Network
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.565
Publications: 4 Organism: Rattus Norvegicus, Mus Musculus, Homo Sapiens
Tissue: Myotome, Skeletal Muscle
Pathways:COVID-19 Causal Network, WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation SRSF1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GJA5 0.313
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ACACA 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation ITPKA 0.334
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation DUOX1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TAL1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PLCG1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GFAP 0.288
Publications: 3 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation ITGB4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDK18 0.226
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation CAD 0.313
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CAD 0.313
Publications: 1
+ img/unknown.png phosphorylation MBP 0.355
Publications: 6 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation LRRK2 0.417
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation SCRIB 0.252
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation LASP1 0.312
Publications: 3 Organism: In Vitro, Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDK16 0.32
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation PHOX2A 0.313
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AQP5 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AKAP13 0.338
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation VASP 0.491
Publications: 4 Organism: Homo Sapiens, In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation CACNA1S 0.33
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation ITPR1 0.54
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PLN 0.473
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation HSPB6 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation STMN1 0.315
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTBP1 0.315
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation PIN1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP2 0.369
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SRC 0.369
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SRC 0.369
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CACNA1D 0.375
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation TAL1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOXA1 0.33
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PRKAA2 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARHGDIA 0.365
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RGS10 0.342
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PPP1R8 0.5
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation MAP2 0.369
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation RAP1B 0.508
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RAP1A 0.507
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation SOX9 0.448
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.2
Publications: 3 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ img/unknown.png phosphorylation CAD 0.313
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation RHOA 0.504
Publications: 1 Organism: Mus Musculus
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation FRAT1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CACNA1C 0.483
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation TPH2 0.257
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ETV1 0.298
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GP1BB 0.318
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation AANAT 0.327
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation APC 0.313
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KDELR1 0.315
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3A 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FYN 0.438
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FLNA 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY
+ up-regulates activity img/direct-activation.png phosphorylation RGS18 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PLIN1 0.486
Publications: 3 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation MIP 0.318
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation TNNI3 0.399
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RAF1 0.485
Publications: 4 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:COVID-19 Causal Network
+ img/unknown.png phosphorylation GJB1 0.313
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation CCND1 0.34
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation IGF2R 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ESR1 0.47
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TFAP2A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NFATC1 0.36
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation VIM 0.315
Publications: 6 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.485
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ up-regulates activity img/direct-activation.png phosphorylation RGS14 0.345
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation RXRA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GPKOW 0.313
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation RRAD 0.347
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation AKAP13 0.338
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MYBPC3 0.279
Publications: 4 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation RELA 0.498
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HDAC5 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RYR2 0.462
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation RYR1 0.333
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation DSP 0.335
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KCNJ13 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.47
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PSEN1 0.476
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation PDE3A 0.498
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PACSIN2 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TPPP 0.2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation HSF1 0.319
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MC4R 0.315
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TBXA2R 0.475
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation USP20 0.317
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation ETV1 0.298
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NFKB1 0.491
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SREBF1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTPRR 0.35
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation SUFU 0.446
Publications: 2 Organism: Homo Sapiens
Pathways:Sonic Hedgehog
+ up-regulates img/direct-activation.png phosphorylation SUFU 0.446
Publications: 3 Organism: Homo Sapiens
Pathways:Sonic Hedgehog
+ up-regulates activity img/direct-activation.png phosphorylation FOS 0.505
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation CSK 0.345
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation WT1 0.349
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EEF2K 0.311
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation ETV5 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KCNK9 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation AICDA 0.331
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation KCNJ3 0.327
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HDAC8 0.475
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KCNK3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HRH1 0.2
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation VTN 0.313
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation TH 0.378
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation ADD1 0.317
Publications: 3 Organism: In Vitro
+ img/unknown.png phosphorylation LCK 0.335
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation STK11 0.483
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation BRAF 0.628
Publications: 2 Organism: In Vitro, Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation KCNJ12 0.288
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation PTPN7 0.37
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PDE3B 0.465
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation GABRR1 0.291
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation NEDD4L 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LRP1 0.331
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png phosphorylation ACLY 0.315
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation POLD3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KCNN2 0.2
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PFKFB2 0.457
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation ASIC1 0.333
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1 0.403
Publications: 3 Organism: Rattus Norvegicus, Homo Sapiens
+ img/unknown.png phosphorylation RAP1GAP 0.315
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation SLC2A2 0.315
Publications: 3 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation LCP1 0.333
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation STMN2 0.315
Publications: 2 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation SNAPIN 0.313
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation CACNB2 0.42
Publications: 3
+ down-regulates img/direct_inhibition.png phosphorylation NF2 0.381
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ALOX5 0.342
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation IMMT 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation MAPT 0.447
Publications: 4 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation TFAM 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CTNNB1 0.462
Publications: 3 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation MCOLN1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PDE4B 0.591
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation PPP2R5D 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAPT 0.447
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation YWHAZ 0.551
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TPH1 0.358
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation ARPP21 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation ACADVL 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation NOS3 0.375
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NOLC1 0.313
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation NOLC1 0.313
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKAP12 0.2
Publications: 4 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation ATF1 0.442
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation ARHGEF6 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation THOP1 0.314
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PIM1 0.269
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CFTR 0.47
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CFTR 0.47
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PKD2L1 0.2
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRK2 0.2
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation RET 0.376
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CD44 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GYS1 0.493
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation HMGN1 0.313
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ARHGAP17 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ADD2 0.288
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRIK2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DYNLRB1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CUL5 0.329
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png phosphorylation CFTR 0.47
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MYOM2 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ img/unknown.png phosphorylation GYS1 0.493
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GMFB 0.313
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation FXYD1 0.433
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FXYD1 0.433
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation LIPE 0.587
Publications: 3 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation LIPE 0.587
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCOA3 0.342
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRIA4 0.418
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRIA1 0.479
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HNRNPD 0.357
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HMGCR 0.34
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png phosphorylation CTNND1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ up-regulates activity img/direct-activation.png phosphorylation KCNQ5 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ARFGEF1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GABBR2 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation TRPM8 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SYN1 0.345
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.545
Publications: 1 Organism: Homo Sapiens
Pathways:Sonic Hedgehog, WNT/FLT3
+ up-regulates img/direct-activation.png phosphorylation RASGRF1 0.505
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CBX3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation NFKB1 0.491
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation PPP1R9B 0.317
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HAND1 0.301
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation LASP1 0.312
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation CAMKK1 0.2
Publications: 1 Organism: Rattus Norvegicus
+ img/unknown.png phosphorylation CHCHD3 0.2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation NDE1 0.376
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ img/unknown.png phosphorylation SNAP25 0.333
Publications: 1 Organism: Rattus Norvegicus
+ img/unknown.png phosphorylation PDE10A 0.376
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SRF 0.258
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation STK24 0.218
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney
+ img/unknown.png phosphorylation CLDN3 0.313
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GNA13 0.374
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png phosphorylation SPTBN1 0.338
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation AURKA 0.494
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation APOBEC3G 0.331
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CACNG2 0.422
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation PPP1R1B 0.486
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation CAPN2 0.265
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation RGS13 0.342
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation CA9 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation UBE3A 0.335
Publications: 1 Organism: Mus Musculus
Tissue: Brain
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation MORC2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ERBB2 0.381
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HSP90AA1 0.461
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GLI3 0.447
Publications: 2 Organism: Homo Sapiens
Pathways:Sonic Hedgehog
+ up-regulates img/indirect-activation.png PRKACA 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, WNT/FLT3
+ img/unknown.png phosphorylation NOS1 0.327
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation LATS1/2 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png chemical activation PRKACA 0.8
Publications: 2 Organism: Homo Sapiens
Pathways:Sonic Hedgehog, WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png binding PRKACA 0.878
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AMPA 0.49
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CSNK1A1L 0.375
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PRKACA 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation AMPK 0.389
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png relocalization PRKACA 0.2
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation LATS1 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding PRKACA 0.386
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GLI1 0.535
Publications: 1
Pathways:Sonic Hedgehog
+ up-regulates img/direct-activation.png phosphorylation LATS2 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation LRP6 0.2
Publications: 1 Organism: Rattus Norvegicus
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation PDE4D 0.564
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PIM 0.269
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization PRKACA 0.545
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation AMPA 0.49
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PRKACA 0.872
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition PRKACA 0.8
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation GLI2 0.447
Publications: 1 Organism: Homo Sapiens
Pathways:Sonic Hedgehog
+ down-regulates activity img/direct_inhibition.png phosphorylation NEFL 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation Histone H3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NfKb-p65/p50 0.495
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ up-regulates img/indirect-activation.png PRKACA 0.254
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GLI2 0.447
Publications: 2 Organism: Homo Sapiens
Pathways:Sonic Hedgehog
+ up-regulates activity img/indirect-activation.png PPARG 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding PRKACA 0.883
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GLIS2 0.286
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PRKACA 0.851
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PHKA2 0.308
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PRKACA 0.271
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/indirect-activation.png PRKACA 0.493
Publications: 1 Organism: Homo Sapiens
Pathways:Sonic Hedgehog, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation ITPKB 0.359
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png binding PRKACA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PRKACA 0.298
Publications: 1 Organism: Homo Sapiens