Summary

Name PRKACA
Full Name cAMP-dependent protein kinase catalytic subunit alpha
Synonyms PKA C-alpha | PKACA
Primary ID P17612
Links - -
Type protein
Relations 351
Pathways Hedgehog, WNT Signaling, WNT Signaling and Myogenesis
Function Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT). Phosphorylates APOBEC3G and AICDA. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1
Publications: 3 Organism: Homo Sapiens, Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation NF2 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation DNAJC5 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SYN2 0.14
Publications: 1 Organism: In Vitro
+ down-regulates quantity img/direct_inhibition.png phosphorylation GLI3 0.45
Publications: 6 Organism: Homo Sapiens
Pathways:Hedgehog
+ up-regulates activity img/direct-activation.png phosphorylation PHKA1 0.14
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation ITGA4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ABCA1 0.22
Publications: 2 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation CIITA 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HAND1 0.14
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation H3F3A 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.14
Publications: 3 Organism: Homo Sapiens
Tissue: Ovary
+ down-regulates img/direct_inhibition.png phosphorylation PLCB3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KCNH2 0.14
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKAR2B 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TENT2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOS3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.24
Publications: 6 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.24
Publications: 3 Organism: Chlorocebus Aethiops, Homo Sapiens, In Vitro
+ up-regulates img/direct-activation.png phosphorylation SRSF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GJA5 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ITPKA 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation DUOX1 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TAL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PLCG1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GFAP 0.14
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.48
Publications: 4 Organism: Rattus Norvegicus, Mus Musculus, Homo Sapiens
Tissue: Skeletal Muscle, Myotome
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation ITGB4 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CAD 0.2
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation CAD 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MBP 0.14
Publications: 6 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation LRRK2 0.22
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation LASP1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LASP1 0.14
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CDK16 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation PHOX2A 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AKAP13 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation VASP 0.37
Publications: 2 Organism: Homo Sapiens, In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation VASP 0.31
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ITPR1 0.14
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation HSPB6 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ up-regulates img/direct-activation.png phosphorylation PIN1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation STMN1 0.2
Publications: 4 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png phosphorylation PLN 0.22
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP2 0.14
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP2 0.14
Publications: 4 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png phosphorylation RGS10 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SRC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SRC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TAL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOXA1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PRKAA2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARHGDIA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PPP1R8 0.14
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation RAP1B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RAP1A 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation SOX9 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.14
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CAD 0.14
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation RHOA 0.28
Publications: 1 Organism: Mus Musculus
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation FRAT1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CACNA1C 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Arterial Smooth Muscle
+ up-regulates img/direct-activation.png phosphorylation TPH2 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png phosphorylation GP1BB 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ETV1 0.14
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AANAT 0.14
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation APC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KDELR1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FYN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FLNA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PLIN1 0.22
Publications: 3 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation MIP 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation TNNI3 0.22
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ img/unknown.png phosphorylation GJB1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation RAF1 0.2
Publications: 3 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation CCND1 0.14
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation IGF2R 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ESR1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TFAP2A 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NFATC1 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation VIM 0.14
Publications: 6 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RGS14 0.14
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RRAD 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation AKAP13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MYBPC3 0.14
Publications: 4 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation RELA 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HDAC5 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RYR2 0.31
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation RYR1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation DSP 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KCNJ13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PSEN1 0.14
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation PDE3A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HSF1 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MC4R 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TBXA2R 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation NFKB1 0.45
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SREBF1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTPRR 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation SUFU 0.37
Publications: 2 Organism: Homo Sapiens
Pathways:Hedgehog
+ up-regulates img/direct-activation.png phosphorylation SUFU 0.37
Publications: 3 Organism: Homo Sapiens
Pathways:Hedgehog
+ down-regulates quantity by repression img/direct_inhibition.png phosphorylation FOS 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation CSK 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation WT1 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EEF2K 0.14
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation ETV5 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KCNK9 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation AICDA 0.34
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation KCNJ3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HDAC8 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KCNK3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HRH1 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation VTN 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation TH 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation ADD1 0.14
Publications: 3 Organism: In Vitro
+ img/unknown.png phosphorylation LCK 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation STK11 0.14
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation BRAF 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation KCNJ12 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation PTPN7 0.2
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PDE3B 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation NEDD4L 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LRP1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png phosphorylation ACLY 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation POLD3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KCNN2 0.14
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PFKFB2 0.14
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation ASIC1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ img/unknown.png phosphorylation RAP1GAP 0.14
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation SLC2A2 0.14
Publications: 3 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation LCP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SNAPIN 0.14
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation STMN2 0.14
Publications: 2 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation CACNB2 0.14
Publications: 3
+ down-regulates img/direct_inhibition.png phosphorylation NF2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAPT 0.24
Publications: 4 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation TFAM 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CTNNB1 0.34
Publications: 3 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation MCOLN1 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PDE4B 0.22
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation PPP2R5D 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAPT 0.24
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation YWHAZ 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TPH1 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation NOS3 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NOLC1 0.14
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation NOLC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATF1 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation THOP1 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PIM1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CFTR 0.23
Publications: 6 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CFTR 0.23
Publications: 4 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRK2 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation RET 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CD44 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GYS1 0.2
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation HMGN1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ADD2 0.14
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRIK2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DYNLRB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CUL5 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation MYOM2 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ img/unknown.png phosphorylation GYS1 0.14
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation FXYD1 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GMFB 0.14
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation LIPE 0.22
Publications: 3 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation LIPE 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCOA3 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRIA4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRIA1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HNRNPD 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HMGCR 0.14
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png phosphorylation CTNND1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ down-regulates activity img/direct_inhibition.png phosphorylation SYN1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Hedgehog
+ up-regulates img/direct-activation.png phosphorylation RASGRF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CBX3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PPP1R9B 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HAND1 0.14
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation CAMKK1 0.14
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation NDE1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ img/unknown.png phosphorylation SNAP25 0.14
Publications: 1 Organism: Rattus Norvegicus
+ img/unknown.png phosphorylation PDE10A 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SRF 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ img/unknown.png phosphorylation STK24 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney
+ img/unknown.png phosphorylation CLDN3 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GNA13 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png phosphorylation SPTBN1 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation AURKA 0.22
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation APOBEC3G 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CACNG2 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation PPP1R1B 0.14
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation CAPN2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation RGS13
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation CA9 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation UBE3A 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation ERBB2 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HSP90AA1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PRKACA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GLI2 0.48
Publications: 2 Organism: Homo Sapiens
Pathways:Hedgehog
+ up-regulates activity img/indirect-activation.png PRKACA 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png binding PRKACA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation PRKACA 0.34
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PIM 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PDE4D 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation AMPK 0.14
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation LATS1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation LRP6 0.22
Publications: 1 Organism: Rattus Norvegicus
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation NfKb-p65/p50 0.2
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation NOS1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation GLIS2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NEFL 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png PRKACA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png PRKACA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CSNK1A1L 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PRKACA 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png binding PRKACA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LATS2 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation ITPKB 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/indirect-activation.png PPARG 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation GLI2 0.39
Publications: 1 Organism: Homo Sapiens
Pathways:Hedgehog
+ down-regulates img/direct_inhibition.png phosphorylation GLI1 0.22
Publications: 1
Pathways:Hedgehog
+ down-regulates img/direct_inhibition.png phosphorylation GLI3 0.45
Publications: 2 Organism: Homo Sapiens
Pathways:Hedgehog
+ down-regulates activity img/direct_inhibition.png binding PRKACA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PRKACA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PRKACA 0.14
Publications: 1 Organism: Homo Sapiens