3.0
Summary
| Name |  KMT2DView Modifications |
| Full Name | Histone-lysine N-methyltransferase 2D |
| Synonyms | Lysine N-methyltransferase 2D, ALL1-related protein, Myeloid/lymphoid or mixed-lineage leukemia protein 2 | ALR, MLL2, MLL4 |
| Primary ID | O14686 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SGK1 | down-regulates activity 
phosphorylation
|
KMT2D | 0.287 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KMT2D | form complex 
binding
|
HMT | 0.829 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity 
ubiquitination
|
KMT2D | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KMT2D | up-regulates
binding
|
ESR1 | 0.466 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KMT2D | form complex
binding
|
MLL2 complex | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PAX7 | up-regulates
binding
|
KMT2D | 0.31 |
| Publications: | 1 | Organism: | Homo Sapiens | |