Summary

Name KMT2D
Full Name Histone-lysine N-methyltransferase 2D
Synonyms Lysine N-methyltransferase 2D, ALL1-related protein, Myeloid/lymphoid or mixed-lineage leukemia protein 2 | ALR, MLL2, MLL4
Primary ID O14686
Links - -
Type protein
Relations 4
Function Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding KMT2D 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ form complex img/form-complex.png binding MLL2 complex 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ESR1 0.35
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding HMT 0.14
Publications: 1 Organism: Homo Sapiens