| + |
KMT2D | form complex 
binding
|
HMT |
0.835 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154763 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17500065 |
The evolutionarily conserved hdpy-30, ash2l, rbbp5, and wdr5 likely constitute a subcomplex that is shared by all human set1-like hmt complexes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ASH2L | form complex
binding
|
HMT |
0.873 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154760 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17500065 |
The evolutionarily conserved hdpy-30, ash2l, rbbp5, and wdr5 likely constitute a subcomplex that is shared by all human set1-like hmt complexes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMT | up-regulates 
|
Protein_methylation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281140 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17500065 |
Here we show that while ectopically expressed PTIP is capable of interacting with DNA damage response proteins including 53BP1, endogenous PTIP, and a novel protein PA1 are both components of a Set1-like histone methyltransferase (HMT) complex that also contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, SET domain-containing HMTs MLL3 and MLL4, and substoichiometric amount of JmjC domain-containing putative histone demethylase UTX. PTIP complex carries robust HMT activity and specifically methylates lysine 4 (K4) on histone H3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMT | up-regulates activity 
methylation
|
Histone H3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281139 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17500065 |
Here we show that while ectopically expressed PTIP is capable of interacting with DNA damage response proteins including 53BP1, endogenous PTIP, and a novel protein PA1 are both components of a Set1-like histone methyltransferase (HMT) complex that also contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, SET domain-containing HMTs MLL3 and MLL4, and substoichiometric amount of JmjC domain-containing putative histone demethylase UTX. PTIP complex carries robust HMT activity and specifically methylates lysine 4 (K4) on histone H3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WDR5 | form complex
binding
|
HMT |
0.892 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154766 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17500065 |
The evolutionarily conserved hdpy-30, ash2l, rbbp5, and wdr5 likely constitute a subcomplex that is shared by all human set1-like hmt complexes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
HMT