| + |
MIR1-1 | down-regulates quantity 
post transcriptional regulation
|
PAX7 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256124 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24708856 |
In this study, bioinformatic prediction combined with pathway analysis and validation by qRT-PCR revealed that miR-155 expression positively correlates with the expression of the AP-1 genes c-JUN and FOS, which are known to induce myeloid differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML |
| + |
PAX7 | up-regulates 
binding
|
MLL2 complex |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217712 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 22863532 |
Carm1 specifically methylates multiple arginines in the n-terminus of pax7. Methylated pax7 directly binds the c-terminal cleavage forms of the trithorax proteins mll1/2 resulting in the recruitment of the ash2l:mll1/2:wdr5:rbbp5 histone h3k4 methyltransferase complex to regulatory enhancers and the proximal promoter of myf5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
PAX7 | up-regulates
binding
|
KMT2A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198626 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22863532 |
Carm1 specifically methylates multiple arginines in the n-terminus of pax7. Methylated pax7 directly binds the c-terminal cleavage forms of the trithorax proteins mll1/2 resulting in the recruitment of the ash2l:mll1/2:wdr5:rbbp5 histone h3k4 methyltransferase complex to regulatory enhancers and the proximal promoter of myf5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CARM1 | up-regulates
methylation
|
PAX7 |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255898 |
|
|
Mus musculus |
Satellite Cell |
| pmid |
sentence |
| 29681515 |
Carm1 specifically methylates Pax7 at multiple arginine residues in the N terminus of Pax7 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198617 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 22863532 |
Carm1 specifically methylates multiple arginines in the n-terminus of pax7. Methylated pax7 directly binds the c-terminal cleavage forms of the trithorax proteins mll1/2 resulting in the recruitment of the ash2l:mll1/2:wdr5:rbbp5 histone h3k4 methyltransferase complex to regulatory enhancers and the proximal promoter of myf5. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Tissue: |
Skeletal Muscle, Muscle, Skeletal Muscle |
| + |
PAX7 | form complex 
binding
|
PAX7/MLL1 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198632 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 22863532 |
Carm1 specifically methylates multiple arginines in the n-terminus of pax7. Methylated pax7 directly binds the c-terminal cleavage forms of the trithorax proteins mll1/2 resulting in the recruitment of the ash2l:mll1/2:wdr5:rbbp5 histone h3k4 methyltransferase complex to regulatory enhancers and the proximal promoter of myf5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
PAX7 | down-regulates quantity by destabilization 
|
MYOD1 |
0.618 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255637 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17548510 |
Previously, we showed that Pax7 overexpression in adult primary myoblasts down-regulates MyoD and prevents myogenin induction, inhibiting myogenesis. We show that Pax7 prevents muscle differentiation independently of its transcriptional activity, affecting MyoD function. [...] Pax7 expression affects MyoD protein stability |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma |
| + |
PAX7 | up-regulates
binding
|
MLL1 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217716 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 22863532 |
Carm1 specifically methylates multiple arginines in the n-terminus of pax7. Methylated pax7 directly binds the c-terminal cleavage forms of the trithorax proteins mll1/2 resulting in the recruitment of the ash2l:mll1/2:wdr5:rbbp5 histone h3k4 methyltransferase complex to regulatory enhancers and the proximal promoter of myf5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
Polycomb repressive complex 2 | down-regulates quantity by repression
transcriptional regulation
|
PAX7 |
0.376 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253598 |
|
|
|
|
| pmid |
sentence |
| 20887952 |
The results presented above demonstrate a signal-dependent interaction between p38a, YY1, and EZH2 on the chromatin of the Pax7 regulatory elements that coincides with p38-mediated repression of Pax7 at early stages of myoblast differentiation. |
|
| Publications: |
1 |
| + |
PAX7 | up-regulates quantity by expression 
transcriptional regulation
|
MYOD1 |
0.618 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181624 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18854138 |
Our cell-based assays and in vitro studies reveal a tight codependent partnership between foxo3 and pax3/7 to coordinately recruit rna polymerase ii and form a preinitiation complex (pic) to activate myod transcription in myoblasts. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma |
| + |
PAX7 | down-regulates
|
Skeletal_muscle_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219371 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22493066 |
Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-Renewal of Skeletal Muscle Satellite Cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle, Satellite Cell |
| Pathways: | NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma |
| + |
PAX7 | up-regulates
binding
|
KMT2D |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198629 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22863532 |
Carm1 specifically methylates multiple arginines in the n-terminus of pax7. Methylated pax7 directly binds the c-terminal cleavage forms of the trithorax proteins mll1/2 resulting in the recruitment of the ash2l:mll1/2:wdr5:rbbp5 histone h3k4 methyltransferase complex to regulatory enhancers and the proximal promoter of myf5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH1 | up-regulates quantity by expression
|
PAX7 |
0.401 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219374 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22493066 |
Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-Renewal of Skeletal Muscle Satellite Cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle, Satellite Cell |
| Pathways: | Acute Myeloid Leukemia, NOTCH Signaling and Myogenesis |
| + |
RBPJ/NOTCH | up-regulates quantity by expression
transcriptional regulation
|
PAX7 |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255365 |
|
|
|
|
| pmid |
sentence |
| 22493066 |
Both binding sites were enriched by more than 5-fold in the ChIP assay with RBP-Jk antibody, suggesting that RBP-Jk occupies these sequences in the Pax7 promoter region. |
|
| Publications: |
1 |
| Tissue: |
Skeletal Muscle |
| Pathways: | NOTCH Signaling and Myogenesis |
| + |
SUZ12/EZH2/YY1 | down-regulates quantity by repression
transcriptional regulation
|
PAX7 |
0.331 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235583 |
|
|
Mus musculus |
C2C12 Cell, Satellite Cell |
| pmid |
sentence |
| 20887952 |
TNF-activated p38a kinase promotes the interaction between YY1 and PRC2, via threonine 372 phosphorylation of EZH2, the enzy- matic subunit of the complex, leading to the for- mation of repressive chromatin on Pax7 promoter. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PAX7 | form complex
binding
|
PAX7/MLL2 complex |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198635 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 22863532 |
Carm1 specifically methylates multiple arginines in the n-terminus of pax7. Methylated pax7 directly binds the c-terminal cleavage forms of the trithorax proteins mll1/2 resulting in the recruitment of the ash2l:mll1/2:wdr5:rbbp5 histone h3k4 methyltransferase complex to regulatory enhancers and the proximal promoter of myf5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
PAX7 | up-regulates quantity by expression
transcriptional regulation
|
MYF5 |
0.508 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255641 |
|
|
|
|
| pmid |
sentence |
| 18066051 |
Together, these experiments indicate that Pax7 enforces satellite cell commitment by recruiting a HMT complex to Myf5, resulting in transcriptional activation. |
|
| Publications: |
1 |
| + |
PAX7 | down-regulates
|
Differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255367 |
|
|
|
|
| pmid |
sentence |
| 15501225 |
We found that ectopic expression of Pax-7 prevented myogenic differentiation and the induction of myogenin protein. |
|
| Publications: |
1 |
| Tissue: |
Skeletal Muscle |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML |
| + |
NOTCH | up-regulates quantity by expression
|
PAX7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254343 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22493066 |
We provide evidence that notch and deltex may act on e47 by inhibiting signaling through ras because (i) full e47 activity was found to be dependent on ras and (ii) both notch and deltex inhibited gal4-jun, a hybrid transcription factor whose activity is dependent on signaling from ras to sapk/jnk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle, Satellite Cell |
| Pathways: | Acute Myeloid Leukemia |
| + |
mir-206 | down-regulates quantity
post transcriptional regulation
|
PAX7 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255921 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20819939 |
We show that miR-1 and miR-206 facilitate satellite cell differentiation by restricting their proliferative potential. We identify Pax7 as one of the direct regulatory targets of miR-1 and miR-206. Inhibition of miR-1 and miR-206 substantially enhances satellite cell proliferation and increases Pax7 protein level in vivo |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PAX7 | up-regulates quantity by expression
transcriptional regulation
|
MYF5 |
0.508 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255899 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29681515 |
Carm1 specifically methylates Pax7 at multiple arginine residues in the N terminus of Pax7, facilitating the recruitment of the ASH2L:MLL1/2:WDR5:RBBP5 histone H3 lysine 4 (H3K4) methyltransferase complex to the proximal promoter of Myf5 resulting in permissive H3K4 tri-methylation (H3K4me3) of the surrounding chromatin |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RBPJ | up-regulates
binding
|
PAX7 |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196948 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22493066 |
Nicd regulates pax7 through interaction with rbp-j, which binds to two consensus sites upstream of the pax7 gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAX7 | up-regulates
|
Quiescence |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135626 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15843801 |
We have identified a new cell population that expresses the transcription factors pax3 and pax7 (paired box proteins 3 and 7) but no skeletal-muscle-specific markers. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255366 |
|
|
|
|
| pmid |
sentence |
| 15501225 |
Our work presented here provides a possible mechanism involving Pax-7 that allow satellite cells to exit the cell cycle, down-regulate MyoD, and prevent myogenin induction, phenotypes characteristic of the quiescent satellite cell. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, |
| Tissue: |
Skeletal Muscle |
| Pathways: | NOTCH Signaling and Myogenesis |
| + |
MYOG | down-regulates quantity by destabilization
|
PAX7 |
0.506 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255638 |
|
|
Mus musculus |
C3H10T1/2 Cell |
| pmid |
sentence |
| 17548510 |
Indeed, we observed a reduction in Pax7 protein levels upon ectopic myogenin expression in MM14 myoblasts, even under proliferation conditions |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma |
| + |
RBPJ/NOTCH | up-regulates quantity by expression
transcriptional regulation
|
PAX7 |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219365 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22493066 |
Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-Renewal of Skeletal Muscle Satellite Cells NICD regulates Pax7 through interaction with RBP-J_, which binds to two consensus sites upstream of the Pax7 gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle, Satellite Cell |
| Pathways: | NOTCH Signaling and Myogenesis |
3.0
PAX7
- 
- 