Summary

Name TNFSF11
Full Name Tumor necrosis factor ligand superfamily member 11
Synonyms Osteoclast differentiation factor, ODF, Osteoprotegerin ligand, OPGL, Receptor activator of nuclear factor kappa-B ligand, RANKL, TNF-related activation-induced cytokine, TRANCE | OPGL, RANKL, TRANCE
Primary ID O14788
Links - -
Type protein
Relations 5
Function Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/indirect-activation.png Osteoclast_differentiation 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TNFRSF11A 0.891
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TNFRSF11B 0.941
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TNFSF11 0.496
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TNFSF11 0.4
Publications: 1 Organism: Homo Sapiens