| + |
DUSP1 | up-regulates activity 
dephosphorylation
|
RUNX2 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277143 |
Ser118 |
AELVRTDsPNFLCSV |
Homo sapiens |
|
| pmid |
sentence |
| 27031422 |
In a separate study, MKP-1 was shown to induce osteogenesis by dephosphorylating Ser125 on Runx2 isoform type II (37).|MKP-1 increases RUNX2 activity and downregulates MAPK, cyclin D1 in differentiated osteoblasts inducing growth arrest and mineralization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates
phosphorylation
|
RUNX2 |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188343 |
Ser294 |
DPRQAQSsPPWSYDQ |
Homo sapiens |
|
| pmid |
sentence |
| 19801668 |
In this study, we identified two phosphorylation sites in runx2 at ser301 and ser319 that are required for mapk-dependent activation of runx2 transcriptional activity and osteoblast differentiation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188347 |
Ser312 |
SYLSQMTsPSIHSTT |
Homo sapiens |
|
| pmid |
sentence |
| 19801668 |
In this study, we identified two phosphorylation sites in runx2 at ser301 and ser319 that are required for mapk-dependent activation of runx2 transcriptional activity and osteoblast differentiation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDK1 | up-regulates
phosphorylation
|
RUNX2 |
0.479 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143586 |
Ser465 |
MVPGGDRsPSRMLPP |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell |
| pmid |
sentence |
| 16407259 |
In vitro kinase assays using recombinant cdc2 kinase showed that runx2 was phosphorylated at ser(451) the cdc2 inhibitor roscovitine dose dependently inhibited in vivo runx2 dna-binding activity during mitosis and the runx2 mutant s451a exhibited lower dna-binding activity and reduced stimulation of anchorage-independent growth relative to wild type runx2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWTR1 | up-regulates
binding
|
RUNX2 |
0.505 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195218 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22153608 |
Taz binding to the transcription factor runx2 promotes osteoblast lineage specification, whereas taz binding to the transcription factor ppargamma inhibits adipogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD1 | up-regulates
binding
|
RUNX2 |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195642 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smad1 interacts with runx2 on the promoter of target genes and controls osteoblast gene expression and differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1D | up-regulates activity
dephosphorylation
|
RUNX2 |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277110 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23907458 |
Activating dephosphorylation of RUNX2 by Wip1 increases its transcriptional activity on the Bax promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD8/SMAD4 | up-regulates 
transcriptional regulation
|
RUNX2 |
0.479 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255784 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27563484 |
Smad1/5/8-Smad4 complex transcribed Runx2 expression, as they complex with Runx2 to initiate other osteoblast gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EP300 | up-regulates quantity
acetylation
|
RUNX2 |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195579 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Bmp-induced non-smad erk signaling pathway cooperatively regulates osteoblast differentiation, in part, through increasing the stability and transcriptional activity of runx2 or increasing runx2 acetylation by p300. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167966 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20851880 |
These results indicate that Erk signaling increases Runx2 stability and transcriptional activity, partly via increasing p300 protein levels and histone acetyltransferase activity and subsequently increasing Runx2 acetylation by p300 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | down-regulates 
binding
|
NOTCH1 |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167627 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20740684 |
Runx2 is an inhibitor of the notch1 signaling pathway during normal osteoblast differentiation. The n-terminal domain of runx2 was crucial to the binding and inhibition of the the n-terminus of the notch1 intracellular domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
COL1A2 |
0.424 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107166 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331591 |
In addition to osteocalcin, cbfa1 regulates expression of several other genes that are activated during osteoblast |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD5/SMAD4 | up-regulates
transcriptional regulation
|
RUNX2 |
0.58 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255783 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 11073979 |
As shown in Fig. 8A, overexpression of Smad5 by itself induced Runx2 expression even in the absence of BMP-2 (lane 5). Western blot analysis also confirmed the induced level of Runx2 protein in C2C12-Sm5 cells (Fig. 8B) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
MMP13 |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255078 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15564063 |
Increased expression of RUNX2 in OA cartilage may contribute to increased expression of MMP-13. FGF2, which is present in OA synovial fluid, activated RUNX2 via the MEK/ERK pathway and increased MMP-13 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT6B | up-regulates
binding
|
RUNX2 |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-117335 |
|
|
Homo sapiens |
T-lymphocyte, Leukemia Cell, Lymphoma Cell |
| pmid |
sentence |
| 11965546 |
Moz and morf both interact with runx2 / while morf does not acetylate runx2, its sm domain potentiates runx2-dependent transcriptional activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMURF1 | down-regulates activity
ubiquitination
|
RUNX2 |
0.504 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236083 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12738770 |
Smurf1 interacts directly with Cbfa1 and mediates Cbfa1 degradation in a ubiquitin- and proteasome-dependent manner. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-95233 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14701828 |
Recently we have found that smurf1 mediates the protein degradation of the osteoblast-specific transcription factor runx2/cbfa1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
DDX5 | up-regulates
binding
|
RUNX2 |
0.452 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236974 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 17960593 |
P68 (ddx5) interacts with runx2 and regulates osteoblast differentiation. / p68 is a novel co-activator for runx2 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
ELANE |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254552 |
|
|
Homo sapiens |
Bone Marrow Cell |
| pmid |
sentence |
| 14594802 |
We find that LEF-1 and CBFalpha co-activate ELA2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDAC5 | down-regulates
deacetylation
|
RUNX2 |
0.458 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195606 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Hdac4 and hdac5 deacetylate runx2 and lead to a smurf-mediated degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-145983 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16613856 |
Hdac4 and hdac5 deacetylate runx2 and lead to a smurf-mediated degradation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
YAP/TAZ | up-regulates activity
binding
|
RUNX2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277667 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
The WW domains are essential for YAP-induced cell proliferation (261) and mediate binding of YAP/TAZ to PPxY motif-containing transcription factors such as RUNX, p73, and the cytoplasmic domain of ERBB4 or with the transcriptional cofactor WBP2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277672 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
The WW domains are essential for YAP-induced cell proliferation (261) and mediate binding of YAP/TAZ to PPxY motif-containing transcription factors such as RUNX, p73, and the cytoplasmic domain of ERBB4 or with the transcriptional cofactor WBP2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
HDAC4 | down-regulates
deacetylation
|
RUNX2 |
0.525 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146122 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16613856 |
Hdac4 and hdac5 deacetylate runx2 and lead to a smurf-mediated degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195603 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Hdac4 and hdac5 deacetylate runx2 and lead to a smurf-mediated degradation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
TNFSF11 |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107242 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331591 |
In addition to osteocalcin, cbfa1 regulates expression of several other genes that are activated during osteoblast |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates
|
RUNX2 |
0.438 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183532 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19175684 |
In-teractions between beta-catenin and runx2 play an im-portant role in bmp-9-induced osteogenic differentia-tion of mscs. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195570 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
In-teractions between beta-catenin and runx2 play an im-portant role in bmp-9-induced osteogenic differentia-tion of mscs. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
DLX3 | up-regulates quantity by expression
transcriptional regulation
|
RUNX2 |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150177 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17060321 |
Here we show that bmp2 induces dlx3, a homeodomain protein that activates runx2 gene transcription. Small interfering rna knockdown studies in osteoblasts validate that dlx3 is a potent regulator of runx2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK11 | up-regulates
|
RUNX2 |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166167 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20551513 |
Mechanistic analysis revealed that the tak1-mkk3/6-p38 mapk axis phosphorylated runx2, promoting its association with the coactivator creb-binding protein (cbp), which is re-quired to regulate osteoblast genetic programs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD1/5/8/SMAD4 | up-regulates
transcriptional regulation
|
RUNX2 |
0.592 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255836 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27563484 |
Smad1/5/8-Smad4 complex transcribed Runx2 expression, as they complex with Runx2 to initiate other osteoblast gene expression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255835 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 11073979 |
As shown in Fig. 8A, overexpression of Smad5 by itself induced Runx2 expression even in the absence of BMP-2 (lane 5). Western blot analysis also confirmed the induced level of Runx2 protein in C2C12-Sm5 cells (Fig. 8B) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
BGLAP |
0.575 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107160 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331591 |
Tgf-beta inhibited the expression of the cbfa1 and osteocalcin genes, whose expression is controlled by cbfa1 in osteoblast-like cell lines. This inhibition was mediated by smad3, which interacts physically with cbfa1 and represses its transcriptional activity at the cbfa1-binding ose2 promoter sequence |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255408 |
|
|
Mus musculus |
F9-12 Cell, ROS-17/2.8 Cell |
| pmid |
sentence |
| 9182762 |
Indeed, we identified Osf2/Cbfa1 binding sites in the promoter of four genes expressed only (the Osteocalcin genes) or highly (α1(I) collagen, Bsp, and Osteopontin) in osteoblasts. Each of these elements was able to bind Osf2/Cbfa1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| + |
RUNX2 | up-regulates
|
Osteoblast_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48940 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9182762 |
Osf2/cbfa1 as an osteoblast-specific transcription factor and as a regulator of osteoblast differentiation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
MMP2 |
0.326 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255082 |
|
|
Homo sapiens |
Thyroid Cancer Cell Line |
| pmid |
sentence |
| 22641097 |
Effective silencing of Runx2 by short interfering RNA (siRNA) demonstrated downregulation of EMT-related molecules (SNAI2, SNAI3 and TWIST1), MMP2 and vasculogenic factors (VEGFA and VEGFC) in thyroid carcinoma cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | up-regulates
|
RUNX2 |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134512 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15765505 |
Runx2 is an important mediator of the expression of bmp-2 in response to fgf stimulation in cranial bone development. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DLX5 | up-regulates quantity by expression
transcriptional regulation
|
RUNX2 |
0.481 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153454 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17335796 |
Dlx5 can drive runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195576 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Dlx5 can drive runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme , indicat-ing that dlx5 can work as an upstream gene of runx2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
HDAC4 | down-regulates activity
deacetylation, binding
|
RUNX2 |
0.525 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227547 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16613856 |
HDAC4 and HDAC5 deacetylate Runx2, allowing the protein to undergo Smurf-mediated degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226680 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 15537544 |
Here we report that HDAC4, which is expressed in prehypertrophic chondrocytes, regulates chondrocyte hypertrophy and endochondral bone formation by interacting with and inhibiting the activity of Runx2, a transcription factor necessary for chondrocyte hypertrophy.PDPK1 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Chlorocebus Aethiops |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
SNAI2 |
0.392 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255080 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22641097 |
Effective silencing of Runx2 by short interfering RNA (siRNA) demonstrated downregulation of EMT-related molecules (SNAI2, SNAI3 and TWIST1), MMP2 and vasculogenic factors (VEGFA and VEGFC) in thyroid carcinoma cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MKX | up-regulates quantity by expression
transcriptional regulation
|
RUNX2 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267215 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33115953 |
MKX is a meniscus-enriched transcription factor. In human meniscus cells, MKX regulates the expression of meniscus marker genes, OA-related genes, and other transcription factors, including Scleraxis (SCX), SRY Box 5 (SOX5), and Runt domain-related transcription factor 2 (RUNX2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Meniscus |
| + |
YAP1 | down-regulates
binding
|
RUNX2 |
0.45 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195221 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22153608 |
Here we show that the endogenous yes-associated protein (yap), a mediator of src/yes signaling, interacts with the native runx2 protein, an osteoblast-related transcription factor, and suppresses runx2 transcriptional activity in a dose-dependent manner. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-121803 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14765127 |
Here we show that the endogenous yes-associated protein (yap), a mediator of src/yes signaling, interacts with the native runx2 protein, an osteoblast-related transcription factor, and suppresses runx2 transcriptional activity in a dose-dependent manner. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
HDAC5 | down-regulates activity
deacetylation
|
RUNX2 |
0.458 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227550 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16613856 |
HDAC4 and HDAC5 deacetylate Runx2, allowing the protein to undergo Smurf-mediated degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity
transcriptional regulation
|
SPP1 |
0.485 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245336 |
|
|
Mus musculus |
Colorectal Cancer Cell Line |
| pmid |
sentence |
| 16670084 |
Ets-1 and Runx2 are critical transcriptional regulators of OPN expression in CT26 colorectal cancer cells. Suppression of these transcription factors results in significant down-regulation of the OPN metastasis protein. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
KAT6A/KAT6B | up-regulates
binding
|
RUNX2 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217204 |
|
|
Homo sapiens |
T-lymphocyte, Leukemia Cell, Lymphoma Cell |
| pmid |
sentence |
| 11965546 |
Moz and morf both interact with runx2 / while morf does not acetylate runx2, its sm domain potentiates runx2-dependent transcriptional activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B | down-regulates activity
phosphorylation
|
RUNX2 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279051 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17786208 |
Collectively, these data demonstrate that the kinase activity of GSK-3beta suppresses the Runx2 transcriptional activity.|In vitro kinase assay confirmed that the Runx2 phosphorylation by GSK-3\u03b2 was reduced by the S369-S373-S377 mutation ( xref ). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
BMP2 |
0.49 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134515 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15765505 |
Runx2 is an important mediator of the expression of bmp-2 in response to fgf stimulation in cranial bone development |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 | down-regulates activity
phosphorylation
|
RUNX2 |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280176 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23389849 |
Here we show that Akt kinase directly phosphorylates Runx2 to regulate invasive properties of breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
RUNX2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235533 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11331591 |
Together, these results suggest that the inhibition of cbfa1 transcription by TGF-_ requires both the presence of CBFA1 and CBFA1 binding to the cbfa1 promoter. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | TGF-beta Signaling |
| + |
GAS7 | up-regulates quantity by expression
transcriptional regulation
|
RUNX2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202242 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23840221 |
Downregulation of gas7 using short-hairpin rna decreased the expression of runx2, a master regulator of osteogenesis, and its target genes (alkaline phosphatase, type i collagen, osteocalcin, and osteopontin). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | down-regulates quantity by repression 
transcriptional regulation
|
RUNX2 |
0.342 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235998 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331591 |
Tgf-b caused a 50% reduction of cbfa1 mrna. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
RUNX2 | up-regulates
binding
|
CREBBP |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166170 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20551513 |
Mechanistic analysis revealed that the tak1-mkk3/6-p38 mapk axis phosphory-lated runx2, promoting its association with the coac-tivator creb-binding protein (cbp), which is re-quired to regulate osteoblast genetic programs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates
transcriptional regulation
|
SP7 |
0.506 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255410 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16574347 |
Osx promoter activity was up-regulated by 2 fold after Runx2 over-expression in ATDC5 cells. Osx Is Phosphorylated by p38 at Ser-73 and Ser-77 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
COL2A1 |
0.437 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107169 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331591 |
In addition to osteocalcin, cbfa1 regulates expression of several other genes that are activated during osteoblast |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD3 | down-regulates activity
binding
|
RUNX2 |
0.736 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235902 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11331591 |
Tgf-beta inhibited the expression of the cbfa1 and osteocalcin genes, whose expression is controlled by cbfa1 in osteoblast-like cell lines. This inhibition was mediated by smad3, which interacts physically with cbfa1 and represses its transcriptional activity at the cbfa1-binding ose2 promoter sequence. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
RUNX2 |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255777 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20551513 |
Mechanistic analysis revealed that the TAK1–MKK3/6–p38 MAPK axis phosphorylated Runx2, promoting its association with the coactivator CREB-binding protein (CBP), which was required to regulate osteoblast genetic programs. These findings reveal an in vivo function for p38β and establish that MAPK signaling is essential for bone formation in vivo. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | TGF-beta Signaling |
| + |
STUB1 | down-regulates quantity by destabilization
ubiquitination
|
RUNX2 |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278600 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18541707 |
Here, we show that CHIP promotes Runx2 ubiquitination and degradation and thereby negatively regulates osteoblast differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
COL1A1 |
0.448 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107163 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331591 |
In addition to osteocalcin, cbfa1 regulates expression of several other genes that are activated during osteoblast differentiation, including alkaline phosphatase, a1 and a2 collagen, osteopontin and osteoprotegerin ligand. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
TWIST1 |
0.447 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255085 |
|
|
Homo sapiens |
Thyroid Cancer Cell Line |
| pmid |
sentence |
| 22641097 |
Effective silencing of Runx2 by short interfering RNA (siRNA) demonstrated downregulation of EMT-related molecules (SNAI2, SNAI3 and TWIST1), MMP2 and vasculogenic factors (VEGFA and VEGFC) in thyroid carcinoma cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | form complex 
binding
|
RUNX2/EP300 |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255419 |
|
|
Rattus norvegicus |
ROS-17/2.8 Cell |
| pmid |
sentence |
| 12697832 |
More interestingly, the bone-specific transcriptionfactor Runx2/Cbfa1 is present in the immunoprecipitated material, strongly indicating that in osteoblastic cells expressing OC, p300 and Runx2/Cbfa1 are components of the same nuclear protein complex. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
ENPP1 |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252192 |
|
|
Homo sapiens |
MC3T3-E1(C4) Cell |
| pmid |
sentence |
| 19049325 |
FGF2 increases PC-1 and Ank expression while inhibiting Tnap expression in primary pre-osteoblast cells. Additionally, we show that the induction of PC-1 by FGF2 is cell type specific and mediated by the transcription factor, Runx2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TWIST1 | down-regulates quantity by repression
transcriptional regulation
|
RUNX2 |
0.447 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255593 |
|
|
Homo sapiens |
Mesenchymal Stem Cell |
| pmid |
sentence |
| 21931630 |
Using human MSCs, we discovered TWIST, a downstream target of HIF-1α, was induced under hypoxia and acted as a transcription repressor of RUNX2 through binding to the E-box located on the promoter of type 1 RUNX2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD1/5/8/SMAD4 | up-regulates activity
binding
|
RUNX2 |
0.592 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255834 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15573378 |
The Runx2 WT and deletion constructs (1 –495, 1–464, and 1–432) all physically interact with the BMP2 responsive Smad 1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT6A | up-regulates
binding
|
RUNX2 |
0.307 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-117332 |
|
|
Homo sapiens |
T-lymphocyte, Leukemia Cell, Lymphoma Cell |
| pmid |
sentence |
| 11965546 |
Moz and morf both interact with runx2 / while morf does not acetylate runx2, its sm domain potentiates runx2-dependent transcriptional activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
VEGFC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255081 |
|
|
Homo sapiens |
Thyroid Cancer Cell Line |
| pmid |
sentence |
| 22641097 |
Effective silencing of Runx2 by short interfering RNA (siRNA) demonstrated downregulation of EMT-related molecules (SNAI2, SNAI3 and TWIST1), MMP2 and vasculogenic factors (VEGFA and VEGFC) in thyroid carcinoma cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TWIST2 | down-regulates quantity by repression
transcriptional regulation
|
RUNX2 |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255592 |
|
|
Homo sapiens |
Mesenchymal Stem Cell |
| pmid |
sentence |
| 21931630 |
Using human MSCs, we discovered TWIST, a downstream target of HIF-1α, was induced under hypoxia and acted as a transcription repressor of RUNX2 through binding to the E-box located on the promoter of type 1 RUNX2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
VEGFA |
0.442 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255084 |
|
|
Homo sapiens |
Thyroid Cancer Cell Line |
| pmid |
sentence |
| 22641097 |
Effective silencing of Runx2 by short interfering RNA (siRNA) demonstrated downregulation of EMT-related molecules (SNAI2, SNAI3 and TWIST1), MMP2 and vasculogenic factors (VEGFA and VEGFC) in thyroid carcinoma cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
SPP1 |
0.485 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107175 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331591 |
In addition to osteocalcin, cbfa1 regulates expression of several other genes that are activated during osteoblast |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
SNAI3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255083 |
|
|
Homo sapiens |
Thyroid Cancer Cell Line |
| pmid |
sentence |
| 22641097 |
Effective silencing of Runx2 by short interfering RNA (siRNA) demonstrated downregulation of EMT-related molecules (SNAI2, SNAI3 and TWIST1), MMP2 and vasculogenic factors (VEGFA and VEGFC) in thyroid carcinoma cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
ALPL |
0.457 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107123 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331591 |
In addition to osteocalcin, cbfa1 regulates expression of several other genes that are activated during osteoblast |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD1/4 | up-regulates activity
binding
|
RUNX2 |
0.565 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255782 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15573378 |
The Runx2 WT and deletion constructs (1 –495, 1–464, and 1–432) all physically interact with the BMP2 responsive Smad 1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GGCX | up-regulates quantity by expression
transcriptional regulation
|
RUNX2 |
0.298 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261230 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 31539109 |
GGCX can regulate osteoporosis via promoting the TGFβ/smad signaling pathway, facilitating BMSCs osteogenic differentiation, and inhibiting BMSCs adipogenic differentiation. The transfection of pcDNA-GGCX plasmid significantly promoted BMSC cell proliferation, increased calcified nodule formation, inhibited adipogenic differentiation, enhanced ALP activity, elevated RUNX2, and OPN mRNA expressions, and upregulated TGFβ1, Smad2, and Smad7 expressions (p < 0.05). |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
4.0
RUNX2
- 
- 