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Summary
Name
PPEF1
View Modifications
Full Name
Serine/threonine-protein phosphatase with EF-hands 1
Synonyms
PPEF-1, EC 3.1.3.16, Protein phosphatase with EF calcium-binding domain, PPEF, Serine/threonine-protein phosphatase 7, PP7 | PPEF, PPP7C
Primary ID
O14829
Links
-
-
Type
protein
Relations
1
Function
May have a role in the recovery or adaptation response of photoreceptors. May have a role in development.
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by mechanism
none
dephosphorylation
by effect
none
down-regulates quantity by destabilization
by organism:
none
Homo sapiens
by tissue:
none
by cell-line
none
▶
Modifications Tables
PPEF1 as Modifier
Residue
Sequence
Target
Effect
Modification
Ser119
NRRKVMDsDEDDDY
PDCD5
inhibition
dephosphorylation
Relations
Regulator
Mechanism
target
score
ℹ
+
PPEF1
down-regulates quantity by destabilization
dephosphorylation
PDCD5
0.357
Identifier
Residue
Sequence
Organism
Cell Line
SIGNOR-277008
Ser119
NRRKVMDsDEDDDY
Homo sapiens
pmid
sentence
28051100
Here, we report that the serine/threonine phosphatase PPEF-1 interacts with and dephosphorylates PDCD5 at Ser 119, which leads to PDCD5 destabilization.|These results demonstrate that PPEF-1 reduces PDCD5 stability via PDCD5 dephosphorylation.
Publications:
1
Organism:
Homo Sapiens