Summary

Name FFAR1
Full Name Free fatty acid receptor 1
Synonyms G-protein coupled receptor 40 | GPR40
Primary ID O14842
Links - -
Type protein
Relations 8
Function G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding GNAO1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAQ 0.549
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAS 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA12 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation FFAR1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAL 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation FFAR1 0.8
Publications: 1 Organism: Homo Sapiens