Summary

Name ATP2A1
Full Name Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Synonyms SERCA1, SR Ca(2+)-ATPase 1, Calcium pump 1, Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform, Endoplasmic reticulum class 1/2 Ca(2+) ATPase
Primary ID O14983
Links - -
Type protein
Relations 4
Function Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ATP2A1 0.317
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png relocalization calcium(2+) 0.8
Publications: 1 Organism: Oryctolagus Cuniculus
+ down-regulates activity img/direct_inhibition.png binding ATP2A1 0.568
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ATP2A1 0.298
Publications: 1 Organism: Oryctolagus Cuniculus