3.0
Summary
| Name |  SETD1A
|
| Full Name | Histone-lysine N-methyltransferase SETD1A |
| Synonyms | Lysine N-methyltransferase 2F, SET domain-containing protein 1A, hSET1A, Set1/Ash2 histone methyltransferase complex subunit SET1 | KIAA0339, KMT2F, SET1, SET1A |
| Primary ID | O15047 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression (PubMed:12670868). May play a role in synaptic function and the development of neurons (PubMed:31197650). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SETD1A | form complex 
binding
|
Set1-Ash2 HMT complex | 0.896 |
| Publications: | 1 | Organism: | Homo Sapiens | |