| + |
Set1-Ash2 HMT complex | down-regulates activity 
methylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264483 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 12670868 |
The Set1/Ash2 HMT methylates histone H3 at Lys 4 (K4), but not if the neighboring K9 residue is already methylated. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Set1-Ash2 HMT complex | down-regulates activity
methylation
|
H3-3A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264484 |
Lys5 |
kQTARKST |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12670868 |
The Set1/Ash2 HMT methylates histone H3 at Lys 4 (K4), but not if the neighboring K9 residue is already methylated. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Set1-Ash2 HMT complex | down-regulates activity
methylation
|
H3C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264482 |
Lys5 |
kQTARKST |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12670868 |
The Set1/Ash2 HMT methylates histone H3 at Lys 4 (K4), but not if the neighboring K9 residue is already methylated. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WDR5 | form complex 
binding
|
Set1-Ash2 HMT complex |
0.917 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264480 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12670868 |
Our analysis of HCF-1-associated proteins suggests that a K4 histone H3 HMT complex has been conserved from yeast to humans in both structure and activity: the Set1/Ash2 HMT. The results presented here show that this Set1/Ash2 HMT complex, in mutually exclusive interactions, can associate with HCF-1 bound to the repressive Sin3 HDAC or the transcriptional activator VP16, indicating a diversity of transcriptional regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HCFC1 | up-regulates activity 
binding
|
Set1-Ash2 HMT complex |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264481 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12670868 |
Our analysis of HCF-1-associated proteins suggests that a K4 histone H3 HMT complex has been conserved from yeast to humans in both structure and activity: the Set1/Ash2 HMT. The results presented here show that this Set1/Ash2 HMT complex, in mutually exclusive interactions, can associate with HCF-1 bound to the repressive Sin3 HDAC or the transcriptional activator VP16, indicating a diversity of transcriptional regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Set1-Ash2 HMT complex | down-regulates activity
methylation
|
Histone H3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265349 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12670868 |
The Set1/Ash2 HMT methylates histone H3 at Lys 4 (K4), but not if the neighboring K9 residue is already methylated. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Set1-Ash2 HMT complex | form complex
binding
|
MLL/SET subcomplex |
0.844 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204744 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24680668 |
Dimethylation of h3k4 requires a sub-complexincluding wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal corecomplexthat is required for multiple lysine methylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SETD1A | form complex
binding
|
Set1-Ash2 HMT complex |
0.897 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264478 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12670868 |
Our analysis of HCF-1-associated proteins suggests that a K4 histone H3 HMT complex has been conserved from yeast to humans in both structure and activity: the Set1/Ash2 HMT. The results presented here show that this Set1/Ash2 HMT complex, in mutually exclusive interactions, can associate with HCF-1 bound to the repressive Sin3 HDAC or the transcriptional activator VP16, indicating a diversity of transcriptional regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ASH2L | form complex
binding
|
Set1-Ash2 HMT complex |
0.91 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264479 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12670868 |
Our analysis of HCF-1-associated proteins suggests that a K4 histone H3 HMT complex has been conserved from yeast to humans in both structure and activity: the Set1/Ash2 HMT. The results presented here show that this Set1/Ash2 HMT complex, in mutually exclusive interactions, can associate with HCF-1 bound to the repressive Sin3 HDAC or the transcriptional activator VP16, indicating a diversity of transcriptional regulatory roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Set1-Ash2 HMT complex