| + |
PEG3 | up-regulates activity 
binding
|
STAT3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282729 |
|
|
Homo sapiens |
Hepatoma Cell |
| pmid |
sentence |
| 36451866 |
Paternally expressed 3 (PEG3) was responsible for Kras/Erk- and mTOR-driven HCC. Elevated PEG3 protein interacted with STAT3 and promoted its transcriptional activity, resulting in the upregulation of proliferation- and metastasis-related proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PEG3 | up-regulates quantity by expression
transcriptional regulation
|
OXTR |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282730 |
|
|
Mus musculus |
Mammary Epithelial Cell |
| pmid |
sentence |
| 30106994 |
PEG3 directly binds to a genomic region within the 3rd exon of Oxtr, which contains a DNA-binding motif for PEG3. In nursing female mice, removal of PEG3 resulted in the increased expression of Oxtr in mammary epithelial cells and also in the hypothalamus. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PEG3 | down-regulates quantity by repression 
transcriptional regulation
|
ACLY |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282731 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 34048454 |
N the current study, we investigated four potential downstream genes of Peg3, which were identified through ChIP-seq data: Acly, Fasn, Idh1, and Hmgcr. This suggests the transcriptional repressor role of Peg3 in the expression levels of Acly. Overall, this series of analyses confirm the binding of PEG3 to Acly, Fasn, and Hmgcr in MEF and Idh1 in both MEF and neonatal brain.Through individual ChIP experiments, we further confirmed the in vivo binding of PEG3 to the promoter regions of Acly, Fasn, Idh1, and Hmgcr. Expression analyses using two mutant mouse models, CoKO (0x Peg3) and U1(2x Peg3), demonstrated the opposite response of Acly expression levels against the dosage of Peg3 in embryos, suggesting Peg3 as a transcriptional repressor for the expression levels of Acly. On the other hand, the analyses using the mammary gland showed a sex-specific opposite response of the expression levels of Acly, Fasn, and Idh1 against 0x Peg3, with higher levels in females and lower levels in males as compared to the wildtypes (Figs 4 and 5). Overall, this study suggests that Peg3 is involved in regulating the expression levels of key genes in adipogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PEG3 | unknown
transcriptional regulation
|
FASN |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282732 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 34048454 |
N the current study, we investigated four potential downstream genes of Peg3, which were identified through ChIP-seq data: Acly, Fasn, Idh1, and Hmgcr. This suggests the transcriptional repressor role of Peg3 in the expression levels of Acly. Overall, this series of analyses confirm the binding of PEG3 to Acly, Fasn, and Hmgcr in MEF and Idh1 in both MEF and neonatal brain.Through individual ChIP experiments, we further confirmed the in vivo binding of PEG3 to the promoter regions of Acly, Fasn, Idh1, and Hmgcr. Expression analyses using two mutant mouse models, CoKO (0x Peg3) and U1(2x Peg3), demonstrated the opposite response of Acly expression levels against the dosage of Peg3 in embryos, suggesting Peg3 as a transcriptional repressor for the expression levels of Acly. On the other hand, the analyses using the mammary gland showed a sex-specific opposite response of the expression levels of Acly, Fasn, and Idh1 against 0x Peg3, with higher levels in females and lower levels in males as compared to the wildtypes (Figs 4 and 5). Overall, this study suggests that Peg3 is involved in regulating the expression levels of key genes in adipogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PEG3 | unknown
transcriptional regulation
|
IDH1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282733 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 34048454 |
N the current study, we investigated four potential downstream genes of Peg3, which were identified through ChIP-seq data: Acly, Fasn, Idh1, and Hmgcr. This suggests the transcriptional repressor role of Peg3 in the expression levels of Acly. Overall, this series of analyses confirm the binding of PEG3 to Acly, Fasn, and Hmgcr in MEF and Idh1 in both MEF and neonatal brain.Through individual ChIP experiments, we further confirmed the in vivo binding of PEG3 to the promoter regions of Acly, Fasn, Idh1, and Hmgcr. Expression analyses using two mutant mouse models, CoKO (0x Peg3) and U1(2x Peg3), demonstrated the opposite response of Acly expression levels against the dosage of Peg3 in embryos, suggesting Peg3 as a transcriptional repressor for the expression levels of Acly. On the other hand, the analyses using the mammary gland showed a sex-specific opposite response of the expression levels of Acly, Fasn, and Idh1 against 0x Peg3, with higher levels in females and lower levels in males as compared to the wildtypes (Figs 4 and 5). Overall, this study suggests that Peg3 is involved in regulating the expression levels of key genes in adipogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PEG3 | unknown
transcriptional regulation
|
HMGCR |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282734 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 34048454 |
N the current study, we investigated four potential downstream genes of Peg3, which were identified through ChIP-seq data: Acly, Fasn, Idh1, and Hmgcr. This suggests the transcriptional repressor role of Peg3 in the expression levels of Acly. Overall, this series of analyses confirm the binding of PEG3 to Acly, Fasn, and Hmgcr in MEF and Idh1 in both MEF and neonatal brain.Through individual ChIP experiments, we further confirmed the in vivo binding of PEG3 to the promoter regions of Acly, Fasn, Idh1, and Hmgcr. Expression analyses using two mutant mouse models, CoKO (0x Peg3) and U1(2x Peg3), demonstrated the opposite response of Acly expression levels against the dosage of Peg3 in embryos, suggesting Peg3 as a transcriptional repressor for the expression levels of Acly. On the other hand, the analyses using the mammary gland showed a sex-specific opposite response of the expression levels of Acly, Fasn, and Idh1 against 0x Peg3, with higher levels in females and lower levels in males as compared to the wildtypes (Figs 4 and 5). Overall, this study suggests that Peg3 is involved in regulating the expression levels of key genes in adipogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PEG3 | down-regulates quantity by repression
transcriptional regulation
|
GRB10 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282735 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23078764 |
Initially, we identified and characterized a subset of PEG3’s target genes and their DNA-binding motif. PEG3 was also shown to regulate the expression of Pgm2l1 through the binding of the identified motif. A gene expression survey of the validated PEG3 bound genes (from Figure 1) demonstrated multiple responses in which gene expression was either reduced (Grb10, Mapk14, Nt5c1a, Ppargc1b, Setd1a, Syap1, Wnt9a), increased (Dusp1, Pgm2l1), or remained the same (Aebp2, Eml2, Ndufs8, Sdhb). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
PEG3 | down-regulates quantity by repression
transcriptional regulation
|
MAPK14 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282736 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23078764 |
Initially, we identified and characterized a subset of PEG3’s target genes and their DNA-binding motif. PEG3 was also shown to regulate the expression of Pgm2l1 through the binding of the identified motif. A gene expression survey of the validated PEG3 bound genes (from Figure 1) demonstrated multiple responses in which gene expression was either reduced (Grb10, Mapk14, Nt5c1a, Ppargc1b, Setd1a, Syap1, Wnt9a), increased (Dusp1, Pgm2l1), or remained the same (Aebp2, Eml2, Ndufs8, Sdhb). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
PEG3 | down-regulates quantity by repression
transcriptional regulation
|
NT5C1A |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282737 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23078764 |
Initially, we identified and characterized a subset of PEG3’s target genes and their DNA-binding motif. PEG3 was also shown to regulate the expression of Pgm2l1 through the binding of the identified motif. A gene expression survey of the validated PEG3 bound genes (from Figure 1) demonstrated multiple responses in which gene expression was either reduced (Grb10, Mapk14, Nt5c1a, Ppargc1b, Setd1a, Syap1, Wnt9a), increased (Dusp1, Pgm2l1), or remained the same (Aebp2, Eml2, Ndufs8, Sdhb). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282738 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23078764 |
Initially, we identified and characterized a subset of PEG3’s target genes and their DNA-binding motif. PEG3 was also shown to regulate the expression of Pgm2l1 through the binding of the identified motif. A gene expression survey of the validated PEG3 bound genes (from Figure 1) demonstrated multiple responses in which gene expression was either reduced (Grb10, Mapk14, Nt5c1a, Ppargc1b, Setd1a, Syap1, Wnt9a), increased (Dusp1, Pgm2l1), or remained the same (Aebp2, Eml2, Ndufs8, Sdhb). |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
PEG3 | down-regulates quantity by repression
transcriptional regulation
|
PPARGC1B |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282739 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23078764 |
Initially, we identified and characterized a subset of PEG3’s target genes and their DNA-binding motif. PEG3 was also shown to regulate the expression of Pgm2l1 through the binding of the identified motif. A gene expression survey of the validated PEG3 bound genes (from Figure 1) demonstrated multiple responses in which gene expression was either reduced (Grb10, Mapk14, Nt5c1a, Ppargc1b, Setd1a, Syap1, Wnt9a), increased (Dusp1, Pgm2l1), or remained the same (Aebp2, Eml2, Ndufs8, Sdhb). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
PEG3 | down-regulates quantity by repression
transcriptional regulation
|
SETD1A |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282740 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23078764 |
Initially, we identified and characterized a subset of PEG3’s target genes and their DNA-binding motif. PEG3 was also shown to regulate the expression of Pgm2l1 through the binding of the identified motif. A gene expression survey of the validated PEG3 bound genes (from Figure 1) demonstrated multiple responses in which gene expression was either reduced (Grb10, Mapk14, Nt5c1a, Ppargc1b, Setd1a, Syap1, Wnt9a), increased (Dusp1, Pgm2l1), or remained the same (Aebp2, Eml2, Ndufs8, Sdhb). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
PEG3 | down-regulates quantity by repression
transcriptional regulation
|
SYAP1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282741 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23078764 |
Initially, we identified and characterized a subset of PEG3’s target genes and their DNA-binding motif. PEG3 was also shown to regulate the expression of Pgm2l1 through the binding of the identified motif. A gene expression survey of the validated PEG3 bound genes (from Figure 1) demonstrated multiple responses in which gene expression was either reduced (Grb10, Mapk14, Nt5c1a, Ppargc1b, Setd1a, Syap1, Wnt9a), increased (Dusp1, Pgm2l1), or remained the same (Aebp2, Eml2, Ndufs8, Sdhb). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
PEG3 | down-regulates quantity by repression
transcriptional regulation
|
WNT9A |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282742 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23078764 |
Initially, we identified and characterized a subset of PEG3’s target genes and their DNA-binding motif. PEG3 was also shown to regulate the expression of Pgm2l1 through the binding of the identified motif. A gene expression survey of the validated PEG3 bound genes (from Figure 1) demonstrated multiple responses in which gene expression was either reduced (Grb10, Mapk14, Nt5c1a, Ppargc1b, Setd1a, Syap1, Wnt9a), increased (Dusp1, Pgm2l1), or remained the same (Aebp2, Eml2, Ndufs8, Sdhb). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
PEG3 | up-regulates quantity by expression
transcriptional regulation
|
DUSP1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282743 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23078764 |
Initially, we identified and characterized a subset of PEG3’s target genes and their DNA-binding motif. PEG3 was also shown to regulate the expression of Pgm2l1 through the binding of the identified motif. A gene expression survey of the validated PEG3 bound genes (from Figure 1) demonstrated multiple responses in which gene expression was either reduced (Grb10, Mapk14, Nt5c1a, Ppargc1b, Setd1a, Syap1, Wnt9a), increased (Dusp1, Pgm2l1), or remained the same (Aebp2, Eml2, Ndufs8, Sdhb). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
PEG3 | up-regulates quantity by expression
transcriptional regulation
|
PGM2L1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282744 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23078764 |
Initially, we identified and characterized a subset of PEG3’s target genes and their DNA-binding motif. PEG3 was also shown to regulate the expression of Pgm2l1 through the binding of the identified motif. A gene expression survey of the validated PEG3 bound genes (from Figure 1) demonstrated multiple responses in which gene expression was either reduced (Grb10, Mapk14, Nt5c1a, Ppargc1b, Setd1a, Syap1, Wnt9a), increased (Dusp1, Pgm2l1), or remained the same (Aebp2, Eml2, Ndufs8, Sdhb). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
4.0
PEG3
- 
- 