+ |
GSK3B | down-regulates quantity by destabilization
phosphorylation
|
TCAP |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-264852 |
Ser157 |
GALRRSLsRSMSQEA |
Homo sapiens |
|
pmid |
sentence |
32937135 |
GSK-3beta phosphorylates FBXL21 and TCAP to activate FBXL21-mediated, phosphodegron-dependent TCAP degradation.|These results show direct GSK-3beta phosphorylation of TCAP S157 and FBXL21 T33 sites. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TTN |
phosphorylation
|
TCAP |
0.905 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-246925 |
Ser157 |
GALRRSLsRSMSQEA |
Mus musculus |
|
pmid |
sentence |
9804419 |
These data indicate that the activation of titin kinase in differentiating myocytes and the resulting phosphorylation of telethonin are involved in the reorganization of the cytoskeleton during myofibrillogenesis. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
TCAP | up-regulates activity
binding
|
Sarcomere_organization |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-264855 |
|
|
Homo sapiens |
|
pmid |
sentence |
9804419 |
The giant muscle protein titin (connectin) is essential in the temporal and spatial control of the assembly of the highly ordered sarcomeres (contractile units) of striated muscle. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Tissue: |
Skeletal Muscle |
+ |
FBXL21P | down-regulates quantity by destabilization
ubiquitination
|
TCAP |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-264853 |
|
|
Homo sapiens |
|
pmid |
sentence |
32937135 |
FBXL21 is a clock-controlled E3 ligase modulating circadian periodicity via subcellular-specific CRYPTOCHROME degradation. How FBXL21 regulates tissue-specific circadian physiology and what mechanism operates upstream is poorly understood. Here we report the sarcomere component TCAP as a cytoplasmic substrate of FBXL21. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TCAP | up-regulates activity
binding
|
TTN |
0.905 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-264854 |
|
|
Homo sapiens |
|
pmid |
sentence |
32937135 |
TCAP, a core sarcomeric component capping the titin proteins, was identified as a positive hit (Figure 1A). TCAP is a small (19 kDa), highly abundant cytoplasmic protein expressed exclusively in skeletal muscle and the heart (Valle et al., 1997). TCAP interacts with titin through its N-terminal beta sheet to anchor titin to the Z-disc |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Tissue: |
Skeletal Muscle |