3.0
Summary
| Name |  TTNView Modifications |
| Full Name | Titin |
| Synonyms | Connectin, Rhabdomyosarcoma antigen MU-RMS-40.14 |
| Primary ID | Q8WZ42 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TTN |
phosphorylation
|
TCAP | 0.905 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | TTN | up-regulates quantity 
relocalization
|
OBSCN | 0.596 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | cyclosporin A | up-regulates 
|
TTN | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TCAP | up-regulates activity
binding
|
TTN | 0.905 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Skeletal Muscle | |||