Summary

Name INPP4B
Full Name Inositol polyphosphate 4-phosphatase type II
Synonyms Inositol polyphosphate 4-phosphatase type II |
Primary ID O15327
Links - -
Type protein
Relations 1
Function Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612).

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Relations

Regulator Mechanism target score ℹ
+ INPP4Bdown-regulates quantity img/direct_inhibition.png chemical modification phosphatidylinositol bisphosphate 0.8
Publications: 1 Organism: Homo Sapiens