| + |
INPP4B | down-regulates quantity 
chemical modification
|
phosphatidylinositol bisphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252433 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21127264 |
Collectively this data indicates INPP4B is the only PtdIns(3,4)P2 4-phosphatase expressed in breast cancer cells and suggests a correlation between INPP4B and hormone receptor status in human breast cancer |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INPP4B | down-regulates activity
dephosphorylation
|
AKT1 |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277106 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24070612 |
Further, we show that INPP4B but not PTEN is able to reduce tyrosine phosphorylation of Akt1 and both the lipid and PTP activity of INPP4B likely contribute to the reduction of Akt1 phosphorylation.|Further, we show that INPP4B but not PTEN is able to reduce tyrosine phosphorylation of Akt1 and both the lipid and protein tyrosine phosphatase activity of INPP4B likely contribute to the reduction of Akt1 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INPP4B | down-regulates activity
dephosphorylation
|
PTEN |
0.618 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277018 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26411369 |
In support, the increase in PTEN caused by INPP4B knockdown was associated with increased phosphorylation of the Ser380, Thr382, Thr383 and Ser385 cluster of the protein (XREF_FIG), which is known to increase PTEN half-life, in colon cancer cells.|Exogenous INPP4B could pull down and dephosphorylate endogenous PTEN, suggesting that effect of INPP4B on PTEN in colon cancer cells is not due to cell-type-specific characteristics of INPP4B per se.|INPP4B downregulates PTEN in colon cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
INPP4B
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