Summary

Name PTEN
Full Name Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Synonyms Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog | MMAC1, TEP1
Primary ID P60484
Links - -
Type protein
Relations 64
Pathways Acute Myeloid Leukemia, BCR-ABL in AML, Onco-fusion proteins in AML, B-cell activation, Colorectal Carcinoma, Glioblastoma Multiforme, Hepatocellular Tumor, Insulin Signaling, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, PI3K/AKT Signaling, Thyroid cancer
Function Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226, PubMed:16824732). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png dephosphorylation CREB1 0.455
Publications: 1 Organism: Mus Musculus
Pathways:Glioblastoma Multiforme, Malignant Melanoma, PI3K/AKT Signaling
+ up-regulates img/direct-activation.png phosphorylation PTEN 0.643
Publications: 2 Organism: Homo Sapiens
Tissue: Hindbrain
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.691
Publications: 3 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.665
Publications: 6 Organism: Homo Sapiens, In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.343
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation PTEN 0.2
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, Onco-fusion proteins in AML, B-cell activation, Colorectal Carcinoma, Glioblastoma Multiforme, Hepatocellular Tumor, Insulin Signaling, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, PI3K/AKT Signaling, Thyroid cancer
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.629
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.523
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTEN 0.629
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.44
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Insulin Signaling, MTOR Signaling, PI3K/AKT Signaling
+ img/unknown.png phosphorylation PTEN 0.441
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTEN 0.443
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTEN 0.386
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation PTEN 0.578
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PTK2 0.814
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PTEN 0.532
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/indirect_inhibition.png SL1 complex 0.284
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DUSP1 0.335
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PTEN 0.346
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PINK1 0.49
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation STAT5A 0.454
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, Onco-fusion proteins in AML, B-cell activation
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NDRG1 0.408
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png AKT1 0.662
Publications: 2 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PTEN 0.386
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png PIK3CA 0.724
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Glioblastoma Multiforme, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABTB1 0.368
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png transcriptional regulation PTEN 0.296
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SH2B2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTEN 0.69
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png PTEN 0.476
Publications: 1 Organism: Homo Sapiens
Pathways:MTOR Signaling, Prostate Cancer, Thyroid cancer
+ up-regulates img/direct-activation.png binding PTEN 0.65
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation BCR-ABL 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, Onco-fusion proteins in AML
+ down-regulates activity img/direct_inhibition.png binding PTEN 0.606
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EGR2 0.313
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFIL3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PTEN 0.572
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPM1A 0.314
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PREX2 0.606
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PTEN 0.418
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PTEN 0.56
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png AKT 0.662
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, B-cell activation, Glioblastoma Multiforme, Hepatocellular Tumor, Insulin Signaling, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, PI3K/AKT Signaling, Thyroid cancer
+ down-regulates activity img/indirect_inhibition.png PI3K 0.708
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, Onco-fusion proteins in AML, B-cell activation, Hepatocellular Tumor, PI3K/AKT Signaling
+ down-regulates quantity img/direct_inhibition.png chemical modification PIP3 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, B-cell activation, Glioblastoma Multiforme, Hepatocellular Tumor, Insulin Signaling, Malignant Melanoma, MTOR Signaling, Prostate Cancer, PI3K/AKT Signaling, Thyroid cancer
+ up-regulates img/direct-activation.png binding PTEN 0.59
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png GLI1 0.366
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTEN 0.59
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png PIK3CB 0.671
Publications: 1 Organism: Homo Sapiens
Pathways:Insulin Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HCLS1 0.2
Publications: 1 Organism: Homo Sapiens