Summary

Name PTEN
Full Name Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Synonyms Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog | MMAC1, TEP1
Primary ID P60484
Links - -
Type protein
Relations 50
Pathways Insulin Receptor, Glioblastoma Multiforme, Malignant Melanoma, Colorectal Carcinoma, Luminal Breast Cancer, Prostate Cancer, MTOR Signaling, Thyroid cancer
Function Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png dephosphorylation CREB1 0.28
Publications: 1 Organism: Mus Musculus
Pathways:Glioblastoma Multiforme, Malignant Melanoma
+ up-regulates img/direct-activation.png phosphorylation PTEN 0.28
Publications: 2 Organism: Homo Sapiens
Tissue: Hindbrain
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.3
Publications: 3 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.31
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.37
Publications: 6 Organism: Homo Sapiens, In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.44
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation PTEN 0.31
Publications: 3 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Glioblastoma Multiforme, Insulin Receptor, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, Thyroid cancer
+ img/unknown.png phosphorylation PTEN 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Insulin Receptor, MTOR Signaling
+ img/unknown.png phosphorylation PTEN 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTEN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTEN 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PTK2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png GLI1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PTEN 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PTEN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PTEN 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PREX2 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PTEN 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional activation PTEN 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png AKT1 0.34
Publications: 2 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ down-regulates img/direct_inhibition.png dephosphorylation STAT5A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPM1A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTEN 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTEN 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png AKT 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Insulin Receptor, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, Thyroid cancer
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PTEN 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png small molecule catalysis 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate 0.45
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png PIK3CA 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Glioblastoma Multiforme, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer
+ down-regulates img/direct_inhibition.png phosphorylation PTEN 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PTEN 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png PIK3CB 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Insulin Receptor
+ down-regulates activity img/direct_inhibition.png PTEN 0.3
Publications: 1 Organism: Homo Sapiens
Pathways:MTOR Signaling, Prostate Cancer, Thyroid cancer