Summary

Name PTEN
Full Name Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Synonyms Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog | MMAC1, TEP1
Primary ID P60484
Links - -
Type protein
Relations 64
Pathways Acute Myeloid Leukemia, BCR-ABL in AML, Onco-fusion proteins in AML, B-cell activation, Colorectal Carcinoma, Glioblastoma Multiforme, Hepatocellular Tumor, Insulin Signaling, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, PI3K/AKT Signaling, Thyroid cancer
Function Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226, PubMed:16824732). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png dephosphorylation CREB1 0.443
Publications: 1 Organism: Mus Musculus
Pathways:Glioblastoma Multiforme, Malignant Melanoma, PI3K/AKT Signaling
+ up-regulates img/direct-activation.png phosphorylation PTEN 0.641
Publications: 2 Organism: Homo Sapiens
Tissue: Hindbrain
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.341
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.692
Publications: 3 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.667
Publications: 6 Organism: Homo Sapiens, In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.517
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.619
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation PTEN 0.2
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, Onco-fusion proteins in AML, B-cell activation, Colorectal Carcinoma, Glioblastoma Multiforme, Hepatocellular Tumor, Insulin Signaling, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, PI3K/AKT Signaling, Thyroid cancer
+ img/unknown.png phosphorylation PTEN 0.619
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.431
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Insulin Signaling, MTOR Signaling, PI3K/AKT Signaling
+ img/unknown.png phosphorylation PTEN 0.433
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTEN 0.435
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTEN 0.379
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation PTEN 0.583
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PTK2 0.815
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png GLI1 0.359
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png PIK3CB 0.668
Publications: 1 Organism: Homo Sapiens
Pathways:Insulin Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HCLS1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/indirect_inhibition.png SL1 complex 0.28
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DUSP1 0.328
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png PI3K 0.703
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, Onco-fusion proteins in AML, B-cell activation, Hepatocellular Tumor, PI3K/AKT Signaling
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PTEN 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification PIP3 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, B-cell activation, Glioblastoma Multiforme, Hepatocellular Tumor, Insulin Signaling, Malignant Melanoma, MTOR Signaling, Prostate Cancer, PI3K/AKT Signaling, Thyroid cancer
+ up-regulates img/direct-activation.png binding PTEN 0.584
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTEN 0.584
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png AKT 0.65
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, B-cell activation, Glioblastoma Multiforme, Hepatocellular Tumor, Insulin Signaling, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, PI3K/AKT Signaling, Thyroid cancer
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PTEN 0.377
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PTEN 0.529
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png AKT1 0.65
Publications: 2 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ down-regulates activity img/indirect_inhibition.png PIK3CA 0.718
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Glioblastoma Multiforme, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABTB1 0.362
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png PTEN 0.464
Publications: 1 Organism: Homo Sapiens
Pathways:MTOR Signaling, Prostate Cancer, Thyroid cancer
+ up-regulates img/direct-activation.png binding PTEN 0.651
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation BCR-ABL 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, Onco-fusion proteins in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EGR2 0.309
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPM1A 0.311
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PTEN 0.408
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PINK1 0.478
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation STAT5A 0.448
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, Onco-fusion proteins in AML, B-cell activation
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NDRG1 0.398
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png transcriptional regulation PTEN 0.292
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SH2B2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTEN 0.687
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PTEN 0.548
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PTEN 0.602
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFIL3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PTEN 0.563
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PREX2 0.602
Publications: 1 Organism: Homo Sapiens