+ |
MID1 | down-regulates quantity by destabilization
polyubiquitination
|
HMG20B |
0.246 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272317 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
28760657 |
The E3 ubiquitin ligase MID1/TRIM18 promotes atypical ubiquitination of the BRCA2-associated factor 35, BRAF35. MID1 is implicated in BRAF35 ubiquitination promoting atypical poly-ubiquitination via K6-, K27- and K29-linkages. We found that MID1 depletion alters BRAF35 localization in these structures and increases BRAF35 stability affecting its cytoplasmic abundance |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
Ub:E2 | up-regulates activity
ubiquitination
|
MID1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271142 |
|
|
Homo sapiens |
|
pmid |
sentence |
34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MID1 | down-regulates quantity by destabilization
ubiquitination
|
PPP2CA |
0.465 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271467 |
|
|
Homo sapiens |
Embryonic Fibroblast |
pmid |
sentence |
11685209 |
MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation |
|
Publications: |
1 |
Organism: |
Homo Sapiens |