Summary

Name PTPN1
Full Name Tyrosine-protein phosphatase non-receptor type 1
Synonyms Protein-tyrosine phosphatase 1B, PTP-1B | PTP1B
Primary ID P18031
Links - -
Type protein
Relations 96
Pathways Insulin Signaling, Rett syndrome
Inhibitors (E)-3-tosylacrylonitrile
Function Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation PTPN1 0.352
Publications: 3 Organism: In Vitro, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPN1 0.326
Publications: 3 Organism: In Vitro, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPN1 0.366
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTPN1 0.52
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPN1 0.52
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPN1 0.52
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTPN1 0.383
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation PTPN1 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Insulin Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation PTPN1 0.732
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png dephosphorylation JAK2 0.79
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation JAK2 0.79
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation PDGFRB 0.677
Publications: 5 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PDGFRB 0.677
Publications: 5 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.751
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation INSR 0.774
Publications: 6 Organism: Homo Sapiens, Mus Musculus
Pathways:Insulin Signaling
+ up-regulates img/direct-activation.png dephosphorylation ACTN1 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation ACTN1 0.34
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png dephosphorylation MET 0.617
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MET 0.617
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png dephosphorylation CAV1 0.55
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation PTPN1 0.2
Publications: 3 Organism: In Vitro
Pathways:Insulin Signaling, Rett syndrome
+ up-regulates activity img/direct-activation.png phosphorylation PTPN1 0.774
Publications: 3 Organism: In Vitro
Pathways:Insulin Signaling
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK15 0.332
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation ROS1 0.38
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation KRT8 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation STAM2 0.488
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation GHR 0.473
Publications: 4 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png dephosphorylation PTK2 0.357
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.773
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation NFKBIA 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CTTN 0.536
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png dephosphorylation SRC 0.773
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTPN1 0.751
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT5A 0.66
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT5B 0.66
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png dephosphorylation STAT5B 0.66
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.574
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation STAT3 0.574
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation NTRK2 0.388
Publications: 2 Organism: Homo Sapiens
Pathways:Rett syndrome
+ down-regulates activity img/direct_inhibition.png dephosphorylation EPHA3 0.432
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation PRKCD 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation ABL1 0.591
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PTPN1 0.453
Publications: 1
+ img/unknown.png phosphorylation PTPN1 0.348
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation TRPV6 0.612
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PTPN1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation PTK2 0.357
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PTPN1 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ down-regulates img/direct_inhibition.png dephosphorylation TRPV6 0.612
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTPN1 0.45
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation LAT 0.475
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PTPN1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ down-regulates img/direct_inhibition.png dephosphorylation AKT 0.732
Publications: 1 Organism: Homo Sapiens
Pathways:Insulin Signaling
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.732
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation IGF1R 0.853
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation IRS1 0.771
Publications: 1 Organism: In Vitro
Pathways:Insulin Signaling
+ down-regulates img/direct_inhibition.png dephosphorylation BCR-ABL 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png PTPN1 0.421
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation LAT 0.475
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TYK2 0.627
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation BCR 0.335
Publications: 1 Organism: Homo Sapiens