Summary

Name PTPN1
Full Name Tyrosine-protein phosphatase non-receptor type 1
Synonyms Protein-tyrosine phosphatase 1B, PTP-1B | PTP1B
Primary ID P18031
Links - -
Type protein
Relations 116
Pathways Insulin Signaling, Rett syndrome
Inhibitors (E)-3-tosylacrylonitrile
Function Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

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▶Modifications Tables

Relations


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Regulator Mechanism target score ℹ
+ CLK1up-regulates activity img/direct-activation.png phosphorylation PTPN1 0.338
Publications: 3 Organism: In Vitro, Homo Sapiens
+ CLK2up-regulates activity img/direct-activation.png phosphorylation PTPN1 0.315
Publications: 3 Organism: In Vitro, Homo Sapiens
+ PLK1up-regulates activity img/direct-activation.png phosphorylation PTPN1 0.351
Publications: 1 Organism: Homo Sapiens
+ CyclinB/CDK1up-regulates activity img/direct-activation.png phosphorylation PTPN1 0.49
Publications: 1 Organism: Homo Sapiens
+ CDK1up-regulates activity img/direct-activation.png phosphorylation PTPN1 0.49
Publications: 1 Organism: Homo Sapiens
+ CDK1