4.0
Summary
| Name |  INSIG1View Modifications |
| Full Name | Insulin-induced gene 1 protein |
| Synonyms | INSIG-1 | |
| Primary ID | O15503 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKAA1 | up-regulates quantity by stabilization 
phosphorylation
|
INSIG1 | 0.257 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF139 | down-regulates quantity 
ubiquitination
|
INSIG1 | 0.476 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | INSIG1 | down-regulates activity
binding
|
SCAP | 0.769 |
| Publications: | 1 | Organism: | Cricetulus Griseus | |
| + | AMFR | down-regulates quantity by destabilization
ubiquitination
|
INSIG1 | 0.525 |
| Publications: | 1 | Organism: | Homo Sapiens | |