Summary

Name SCAP
Full Name Sterol regulatory element-binding protein cleavage-activating protein
Synonyms SCAP, SREBP cleavage-activating protein | KIAA0199
Primary ID Q12770
Links - -
Type protein
Relations 5
Pathways FAP: INSR
Function Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi

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Relations

Regulator Mechanism target score ℹ
+ INSIG2down-regulates activity img/direct_inhibition.png binding SCAP 0.706
Publications: 1 Organism: Cricetulus Griseus
+ INSIG1down-regulates activity img/direct_inhibition.png binding SCAP 0.759
Publications: 1 Organism: Cricetulus Griseus
+ SCAPup-regulates activity img/direct-activation.png binding, relocalization SREBF1 0.716
Publications: 2 Organism: Cricetulus Griseus
+ SCAPup-regulates activity img/direct-activation.png relocalization SREBF2 0.898
Publications: 1 Organism: Cricetulus Griseus