3.0
Summary
| Name |  TTI1View Modifications |
| Full Name | TELO2-interacting protein 1 homolog |
| Synonyms | Protein SMG10 | KIAA0406, SMG10 |
| Primary ID | O43156 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | down-regulates 
phosphorylation
|
TTI1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TTI1 | up-regulates quantity by stabilization 
binding
|
mTORC2 | 0.643 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FBXO9 | down-regulates quantity by destabilization
binding
|
TTI1 | 0.48 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
TTI1 | 0.254 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TTI1 | up-regulates quantity by stabilization
binding
|
mTORC1 | 0.603 |
| Publications: | 1 | Organism: | Homo Sapiens | |