3.0
Summary
| Name |  PJA2View Modifications |
| Full Name | E3 ubiquitin-protein ligase Praja-2 |
| Synonyms | Praja2, RING finger protein 131, RING-type E3 ubiquitin transferase Praja-2 | KIAA0438, RNF131 |
| Primary ID | O43164 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Function | Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA | up-regulates activity 
phosphorylation
|
PJA2 | 0.2 |
| Publications: | 3 | Organism: | In Vitro | |
| + | Ub:E2 | up-regulates activity
ubiquitination
|
PJA2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PJA2 | down-regulates quantity by destabilization 
polyubiquitination
|
PRKAR1B | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PJA2 | down-regulates quantity by destabilization
polyubiquitination
|
PRKAR2B | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PJA2 | down-regulates quantity by destabilization
polyubiquitination
|
PRKAR2A | 0.333 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PJA2 | down-regulates quantity by destabilization
polyubiquitination
|
PRKAR1A | 0.387 |
| Publications: | 1 | Organism: | Homo Sapiens | |