| + |
AREL1 | down-regulates quantity by destabilization 
ubiquitination
|
SEPTIN4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267670 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23479728 |
Furthermore, the ubiquitination and degradation of SMAC, HtrA2, and ARTS were significantly enhanced in AREL1-expressing cells following apoptotic stimulation, indicating that AREL1 binds to and ubiquitinates cytosolic but not mitochondria-associated forms of IAP antagonists |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKN | down-regulates quantity by destabilization
ubiquitination
|
SEPTIN4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278642 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22792159 |
Thus, Parkin degrades ARTS in a proteasome dependent manner.|Together, these results suggest that Parkin specifically ubiquitinates and degrades ARTS, and that this degradation may be linked to the pro-apoptotic function of ARTS. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
XIAP | down-regulates quantity
ubiquitination
|
SEPTIN4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278801 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22185822 |
Fig. 1 D revealed that co-transfection of ARTS and full length XIAP strongly reduces the levels of ARTS, while co-transfection of ARTS and XIAPdelRING does not change ARTS protein levels.|In this study we show that XIAP also promotes the ubiquitination and degradation of its antagonist ARTS. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SEPTIN4 | down-regulates quantity
binding
|
XIAP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267671 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 15029247 |
The mitochondrial ARTS protein promotes apoptosis through targeting XIAP.|Binding of ARTS to XIAP is direct, as recombinant ARTS and XIAP proteins can bind to each other in vitro. ARTS binding to XIAP is specific and related to its pro-apoptotic function, as mutant forms of ARTS (or related septins) that fail to bind XIAP failed to induce apoptosis. ARTS leads to decreased XIAP protein levels and caspase activation. Our data suggest that ARTS induces apoptosis by antagonizing IAPs. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
3.0
SEPTIN4
- 
- 