| + |
AREL1 | down-regulates quantity by destabilization 
ubiquitination
|
DIABLO |
0.388 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267672 |
Lys191 |
RNHIQLVkLQVEEVH |
Homo sapiens |
NCI-H1299 Cell |
| pmid |
sentence |
| 31732561 |
AREL1 ubiquitinated SMAC, primarily on Lys62 and Lys191 |E701A substitution in the AREL1 HECT domain substantially increased its autopolyubiquitination and SMAC ubiquitination activity, whereas deletion of the last three amino acids at the C terminus completely abrogated AREL1 autoubiquitination and reduced SMAC ubiquitination. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267673 |
Lys62 |
CAVPIAQkSEPHSLS |
Homo sapiens |
NCI-H1299 Cell |
| pmid |
sentence |
| 31732561 |
AREL1 ubiquitinated SMAC, primarily on Lys62 and Lys191 |E701A substitution in the AREL1 HECT domain substantially increased its autopolyubiquitination and SMAC ubiquitination activity, whereas deletion of the last three amino acids at the C terminus completely abrogated AREL1 autoubiquitination and reduced SMAC ubiquitination. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267668 |
|
|
Homo sapiens |
NCI-H1299 Cell |
| pmid |
sentence |
| 23479728 |
Furthermore, the ubiquitination and degradation of SMAC, HtrA2, and ARTS were significantly enhanced in AREL1-expressing cells following apoptotic stimulation, indicating that AREL1 binds to and ubiquitinates cytosolic but not mitochondria-associated forms of IAP antagonists| |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
GSK3B | down-regulates quantity by destabilization
phosphorylation
|
AREL1 |
0.32 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275528 |
Thr783 |
IAAPTHStLPTAHTC |
|
|
| pmid |
sentence |
| 27162139 |
These experiments suggested that GSK3beta phosphorylation of FIEL1 is required for PIAS4 targeting, and FIEL1 residues P779 and phosphorylated T783 are both required for PIAS4 interaction |FIEL1 T783A mutant overexpression completely failed to decrease PIAS4 protein level. |
|
| Publications: |
1 |
| + |
AREL1 | down-regulates quantity by destabilization
ubiquitination
|
HTRA2 |
0.419 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267669 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23479728 |
Furthermore, the ubiquitination and degradation of SMAC, HtrA2, and ARTS were significantly enhanced in AREL1-expressing cells following apoptotic stimulation, indicating that AREL1 binds to and ubiquitinates cytosolic but not mitochondria-associated forms of IAP antagonists |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AREL1 | down-regulates quantity by destabilization
ubiquitination
|
PIAS4 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275575 |
|
|
|
|
| pmid |
sentence |
| 27162139 |
In this study, we discovered a new protein isoform encoded by KIAA0317, termed fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulates the TGFβ signaling pathway through the site-specific ubiquitination of PIAS4.FIEL1 targets PIAS4 using a double locking mechanism that is facilitated by the kinases PKCζ and GSK3β. Specifically, PKCζ phosphorylation of PIAS4 and GSK3β phosphorylation of FIEL1 are both essential for the degradation of PIAS4. |
|
| Publications: |
1 |
| + |
AREL1 | down-regulates quantity by destabilization
ubiquitination
|
MTX2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267674 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 34584540 |
Therefore, these results implied that AREL1 ubiquitinates and promotes the degradation of MTX2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ub:E2 | up-regulates activity 
ubiquitination
|
AREL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271286 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AREL1 | down-regulates quantity by destabilization
ubiquitination
|
SEPTIN4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267670 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23479728 |
Furthermore, the ubiquitination and degradation of SMAC, HtrA2, and ARTS were significantly enhanced in AREL1-expressing cells following apoptotic stimulation, indicating that AREL1 binds to and ubiquitinates cytosolic but not mitochondria-associated forms of IAP antagonists |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
AREL1
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