| + |
GPAA1 | up-regulates quantity by expression 
transcriptional regulation
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261240 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32432756 |
GPAA1 may contribute to the malignant progression of childhood ALL via activating c-myc. Luciferase reporter gene assay demonstrated that overexpression of c-myc remarkably attenuated the Luciferase activity of the wild-type GPAA1 vector without attenuating that of the mutant vector or empty vector, further demonstrating that GPAA1 can be targeted by c-myc. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIGS | up-regulates activity 
binding
|
GPAA1 |
0.892 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261361 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11483512 |
To determine roles for PIG-S and PIG-T, we disrupted these genes in mouse F9 cells by homologous recombination. PIG-S and PIG-T knockout cells were defective in transfer of GPI to proteins, particularly in formation of the carbonyl intermediates. We also demonstrate that PIG-S and PIG-T form a protein complex with GAA1 and GPI8, and that PIG-T maintains the complex by stabilizing the expression of GAA1 and GPI8. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
GPAA1
- 
- 