Relation Results

Summary

Name TGFB1I1
Full Name Transforming growth factor beta-1-induced transcript 1 protein
Synonyms Androgen receptor coactivator 55 kDa protein, Androgen receptor-associated protein of 55 kDa, Hydrogen peroxide-inducible clone 5 protein, Hic-5 | ARA55
Primary ID O43294
Links - -
Type protein
Relations 2
Function Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various in ...
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Type: Score: Layout: SPV 
0.3420.715FYNTGFB1I1PTK2B

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ FYNup-regulates activity img/direct-activation.png phosphorylation TGFB1I1 0.342
Identifier Residue Sequence Organism Cell Line
SIGNOR-262875 Tyr60 SGDKDHLySTVCKPR Chlorocebus aethiops
pmid sentence
Hic-5 is a CAKbeta-binding protein localized at focal adhesions. Here we show that overexpression of CAKbeta or Fyn, but not FAK, enhanced the tyrosine phosphorylation of coexpressed Hic-5 in COS-7 cells. The Y60F mutant of Hic-5 was not phosphorylated, and Hic-5 phosphorylated on tyrosine 60 was bound specifically to the SH2 domain of Csk. Specific phosphorylation of Hic-5 by CAKbeta and Fyn may activate a signaling pathway mediated by Hic-5.
Publications: 1 Organism: Chlorocebus Aethiops
+ PTK2Bup-regulates activity img/direct-activation.png phosphorylation TGFB1I1 0.715
Identifier Residue Sequence Organism Cell Line
SIGNOR-262876 Tyr60 SGDKDHLySTVCKPR Chlorocebus aethiops
pmid sentence
Hic-5 is a CAKbeta-binding protein localized at focal adhesions. Here we show that overexpression of CAKbeta or Fyn, but not FAK, enhanced the tyrosine phosphorylation of coexpressed Hic-5 in COS-7 cells. The Y60F mutant of Hic-5 was not phosphorylated, and Hic-5 phosphorylated on tyrosine 60 was bound specifically to the SH2 domain of Csk. Specific phosphorylation of Hic-5 by CAKbeta and Fyn may activate a signaling pathway mediated by Hic-5.
Publications: 1 Organism: Chlorocebus Aethiops
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