Summary

Name CCP110
Full Name Centriolar coiled-coil protein of 110 kDa
Synonyms Centrosomal protein of 110 kDa, CP110, Cep110 | CEP110, CP110, KIAA0419
Primary ID O43303
Links - -
Type protein
Relations 16
Function Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation CCP110 0.536
Publications: 8 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding CETN2 0.686
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CETN3 0.435
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CCP110 0.561
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CALM1 0.325
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Centrosome_separation 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CALM2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CETN1 0.5
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CALM3 0.333
Publications: 1 Organism: Homo Sapiens