Summary

Name CDK2
Full Name Cyclin-dependent kinase 2
Synonyms Cell division protein kinase 2, p33 protein kinase | CDKN2
Primary ID P24941
Links - -
Type protein
Relations 205
Pathways Adipogenesis
Inhibitors R547; seliciclib; 4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide; PHA-848125; 6-bromo-3-(1-methyl-4-pyrazolyl)-5-(3-piperidinyl)-7-pyrazolo[1,5-a]pyrimidinamine; N-[6,6-dimethyl-5-[(1-methyl-4-piperidinyl)-oxomethyl]-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-methylbutanamide; BMS-265246; 4-(2-methyl-3-propan-2-yl-4-imidazolyl)-N-(4-methylsulfonylphenyl)-2-pyrimidinamine; Dinaciclib; alvocidib; alvocidib hydrochloride; 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide; N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide;
Function Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 (PubMed:12944431).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation ARID4A 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.2
Publications: 4 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RBL2 0.34
Publications: 12 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDC6 0.34
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RBL2 0.4
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation UBE2A 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation WEE1 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TK1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MCM2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDKN1A 0.57
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CROCC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BRCA1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FZR1 0.22
Publications: 2
+ up-regulates img/direct-activation.png phosphorylation DNMT1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CCNA2 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DLG1 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CDK7 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation COIL 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ZBTB16 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PGR 0.14
Publications: 6 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MYOD1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NR3C1 0.22
Publications: 2 Organism: In Vitro
Pathways:Adipogenesis
+ img/unknown.png phosphorylation SMAD3 0.28
Publications: 2 Organism: In Vitro
Pathways:Adipogenesis
+ down-regulates img/direct_inhibition.png phosphorylation LIG3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.34
Publications: 6 Organism: Homo Sapiens
Pathways:Adipogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation SMAD3 0.34
Publications: 3 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates img/direct-activation.png phosphorylation CDC25C 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATRIP 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation UBE2R2 0.14
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation ATRIP 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CCDC6 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates activity img/direct-activation.png phosphorylation RUNX1 0.14
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDC25A 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RUNX1 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates img/direct_inhibition.png phosphorylation CDX2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CHEK1 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDX2 0.14
Publications: 3 Organism: Homo Sapiens,
+ down-regulates img/direct_inhibition.png phosphorylation PGR 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTPN2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TFCP2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.44
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MCM4 0.14
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NFYA 0.14
Publications: 2
+ img/unknown.png phosphorylation RAD9A 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HMGA1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SIRT2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOXK2 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPL12 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CCNE1 0.54
Publications: 3 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates activity img/direct-activation.png phosphorylation UBTF 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation MYBL2 0.2
Publications: 7 Organism: , Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ZC3HC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RRN3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP63 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ID2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ID3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LIG1 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDC6 0.34
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MYBL2 0.2
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SP1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation SKP2 0.28
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation GRK2 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation NPM1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN2D 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKAR1A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PELP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ORC2 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PTHLH 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NPAT 0.37
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation CDK2 0.46
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CDK2 0.46
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDK2 0.52
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation CDK2 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDK2 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates img/direct-activation.png phosphorylation CDK2 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ down-regulates activity img/direct_inhibition.png dephosphorylation CDK2 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDK2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDK7 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.6
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NPM1 0.37
Publications: 2 Organism: Homo Sapiens, Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.28
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates img/direct-activation.png phosphorylation SF3B1 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SF3B1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PPP1CA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDK2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDK2 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates activity img/direct-activation.png phosphorylation EZH2 0.34
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MYBL2 0.14
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation HIRA 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: U2-OS Cell
+ up-regulates activity img/direct-activation.png phosphorylation FOXM1 0.14
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation MCM3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RB1 0.5
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RBBP8 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP73 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PRDX1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDK2 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation CDK2 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition CDK2 0.2
Publications: 1 Organism: In Vitro
+ form complex img/form-complex.png binding CyclinA2/CDK2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDK2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CDK2 0.56
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation CDK2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CDK2 0.2
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition CDK2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDK2 0.45
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CDK2 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition CDK2 0.2
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png binding CDK2 0.47
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CDK2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK2 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CyclinE/CDK2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CDK2 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/indirect_inhibition.png CDK2 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDK2 0.14
Publications: 1 Organism: Homo Sapiens