Summary

Name ADCY6
Full Name Adenylate cyclase type 6
Synonyms ATP pyrophosphate-lyase 6, Adenylate cyclase type VI, Adenylyl cyclase 6, Ca(2+)-inhibitable adenylyl cyclase | KIAA0422
Primary ID O43306
Links - -
Type protein
Relations 6
Function Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ NF1up-regulates img/indirect-activation.png ADCY6 0.266
Publications: 1 Organism: Homo Sapiens
+ ADCY6up-regulates quantity img/direct-activation.png chemical modification 3',5'-cyclic AMP 0.8
Publications: 1 Organism: Homo Sapiens
+ GNAI2down-regulates activity img/direct_inhibition.png binding ADCY6 0.506
Publications: 1 Organism: Spodoptera Frugiperda
+ GNB/GNGdown-regulates activity img/direct_inhibition.png binding ADCY6 0.431
Publications: 1 Organism: Chlorocebus Aethiops
+ GNAI1down-regulates activity img/direct_inhibition.png binding ADCY6 0.525
Publications: 1 Organism: Spodoptera Frugiperda
+ GNAI3down-regulates activity img/direct_inhibition.png binding ADCY6 0.493
Publications: 1 Organism: Spodoptera Frugiperda