| + |
GNB/GNG | up-regulates 
|
PI3K |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255010 |
|
|
|
|
| pmid |
sentence |
| 23994464 |
Similar to PLCβ activation, PI3K-activation by neutrophil GPCRs also occurs primarily through Gβγ subunits, through the unique PI3Kγ isoform which is directly activated by Gβγ dimers |
|
| Publications: |
1 |
| + |
GPCR | up-regulates activity
binding
|
GNB/GNG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255007 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23994464 |
Instead, our current understanding is that the majority of GPCR signal transduction in neutrophils occurs through the G gamma/beta subunit. G-protein-coupled receptors in neutrophils primarily signal through the Gβγ heterodimer, activating two parallel pathways through PLCβ2/3 and PI3Kγ. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNB1 | form complex 
binding
|
GNB/GNG |
0.938 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255004 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23994464 |
Instead, our current understanding is that the majority of GPCR signal transduction in neutrophils occurs through the Gβγ subunit |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNB/GNG | down-regulates activity 
binding
|
CACNA1B |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265067 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20655485 |
The main G b/g-dependent effectors of presynaptic GABAB receptors are P/Q-and N-type voltage-dependent Ca2+ channels. GABAB receptors inhibit these Ca2+ channels at excitatory and inhibitory terminals, thereby restricting neurotransmitter release. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | GABAergic synapse |
| + |
GNG2 | form complex
binding
|
GNB/GNG |
0.938 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255005 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23994464 |
Instead, our current understanding is that the majority of GPCR signal transduction in neutrophils occurs through the Gβγ subunit |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GABA-B receptor | up-regulates activity
binding
|
GNB/GNG |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265068 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20655485 |
The main G b/g-dependent effectors of presynaptic GABAB receptors are P/Q-and N-type voltage-dependent Ca2+ channels. GABAB receptors inhibit these Ca2+ channels at excitatory and inhibitory terminals, thereby restricting neurotransmitter release. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | GABAergic synapse |
| + |
GNB/GNG | up-regulates
|
PLCB2 |
0.528 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255015 |
|
|
|
|
| pmid |
sentence |
| 23994464 |
However, it was later shown that other PLCβ isoforms (particularly PLCβ2 and PLCβ3) can also be directly activated by Gβγ subunits |
|
| Publications: |
1 |
| + |
GNB/GNG | up-regulates
|
PLCB3 |
0.367 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255016 |
|
|
|
|
| pmid |
sentence |
| 23994464 |
However, it was later shown that other PLCβ isoforms (particularly PLCβ2 and PLCβ3) can also be directly activated by Gβγ subunits |
|
| Publications: |
1 |
3.0
GNB/GNG