52 kDa repressor of the inhibitor of the protein kinase
Synonyms
p52rIPK, 58 kDa interferon-induced protein kinase-interacting protein, p58IPK-interacting protein, Death-associated protein 4, THAP domain-containing protein 0, THAP domain-containing protein 12 | DAP4, P52RIPK, PRKRIR, THAP0
Primary ID
O43422
Links
- -
Type
protein
Relations
1
Function
Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.
The mammalian kinases PKR and HRI and the yeast kinase GCN2 specifically phosphorylate Ser-51 on the alpha subunit of the translation initiation factor eIF2.